高强度聚焦超声治疗子宫肌瘤及子宫腺肌病130例

发布时间：2018-09-12 05:15

【摘要】：目的：分析高强度聚焦超声治疗子宫肌瘤及子宫腺肌病的临床疗效及其不良反应的发生率。方法：回顾性研究我院2009年1月至2012年9月130例子宫肌瘤及子宫腺肌病患者高强度聚焦超声治疗前及治疗后随访1、3、6、12个月的临床资料,子宫肌瘤和子宫腺肌病治疗的疗效评价采用超声、超声造影、彩色多普勒血流信号、MRI、细胞学检查比较治疗前及治疗后随访中临床症状改善情况,肌瘤或子宫体积的大小,超声造影图像,病灶内部血流及回声,病变组织细胞结构的改变来进行评价。分析治疗期间和治疗后并发症及不良反应的发生率。结果：治疗后,76例经量增多的子宫肌瘤及子宫腺肌病的患者,治疗后12个月减少到原来的14.5%；40例痛经的子宫腺肌病患者,治疗后12个月减少到原来的20%,40例子宫腺肌病患者增大的子宫体积明显缩小(P0.05)。治疗后第1、3、6、12个月平均缩小率分别为11.1%、22.0%、29.4%、39.0%。90例子宫肌瘤患者103个肌瘤体积明显缩小(P0.05),治疗后第1、3、6、12个月平均缩小率分别为45.7%、63.4%、74.3%、80.4%。治疗后与治疗前相比瘤体内无灌注、回声增强与彩色血流治疗后大部分消失,细胞学检查后发现治疗后病灶细胞破坏与组织坏死等变化。治疗中患者无严重的不良反应发生。结论：高强度聚焦超声治疗子宫肌瘤及子宫腺肌病是一种安全有效的无创治疗方法。
[Abstract]:Objective: to analyze the clinical efficacy and incidence of adverse reactions of high intensity focused ultrasound (HIFU) in the treatment of uterine leiomyoma and adenomyosis. Methods: the clinical data of 130 patients with uterine leiomyoma and adenomyosis from January 2009 to September 2012 were retrospectively studied. The therapeutic effects of hysteromyoma and adenomyosis were evaluated by ultrasound, contrast-enhanced ultrasound, color Doppler flow imaging and MRI.The cytological examination was used to compare the improvement of clinical symptoms, the size of myoma or uterine volume before and after treatment. Contrast-enhanced imaging, intrafocal blood flow and echo, pathological changes in tissue and cell structure were evaluated. The incidence of complications and adverse reactions during and after treatment was analyzed. Results: after treatment, 76 cases of uterine leiomyoma and adenomyosis were reduced to 14.5 cases of dysmenorrhea in 12 months after treatment. After 12 months of treatment, the uterine volume of 40 patients with adenomyosis was significantly reduced (P0.05). After treatment, the mean reduction rates of the first trimester and the 12th month were 11.1and 22.0and 29.49.0.The volume of 103 myomas in 90 patients with hysteromyoma decreased significantly (P0.05), and the average reduction rate at 12 months after treatment was 45.73.474.3c80.4, respectively. After treatment, there was no perfusion in the tumor, echo enhancement and color blood flow disappeared after treatment. Cytological examination showed the changes of cell destruction and tissue necrosis after treatment. No serious adverse reactions occurred in the treatment. Conclusion: high intensity focused ultrasound is a safe and effective method for the treatment of uterine leiomyoma and adenomyosis.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33

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