探讨淋巴脉管间隙浸润对早期宫颈癌预后的影响

发布时间：2018-09-14 12:56

【摘要】：探讨淋巴脉管间隙浸润对早期宫颈癌预后的影响。查阅淋巴脉管间隙浸润(lymphovascular space invasion,LVSI)与早期宫颈癌相关文献,文献涉及早期宫颈癌保守性手术、根治术后长期随访观察LVSI与预后的影响。活检标本与根治术标本比较,分析其对淋巴转移、浸润深度的预测价值。共计34篇文献符合要求,部分文献显示淋巴脉管间隙浸润不是宫颈癌预后的独立危险因素,否定其作为早期宫颈癌保留生育功能的评价指标,而部分文献显示LVSI与预后相关。临床观察发现LVSI阳性患者保守性手术治疗仍应谨慎。淋巴脉管间隙浸润作为早期宫颈癌保留生育功能的评价指标尚存争议,其可能与淋巴转移有关,后者是宫颈癌不良预后的独立危险因素。
[Abstract]:To investigate the effect of lymphatic vascular space infiltration on early prognosis of cervical cancer. The literature related to early cervix cancer and lymphatic vascular interstitial infiltration (lymphovascular space invasion,LVSI) was reviewed. The literature involved conservative surgery for early cervical cancer. The long-term follow-up after radical resection was to observe the influence of LVSI on prognosis. The predictive value of biopsy specimen and radical operation specimen in lymphatic metastasis and depth of invasion was analyzed. A total of 34 articles met the requirements. Some literatures showed that lymphatic vascular space infiltration was not an independent risk factor for the prognosis of cervical cancer. It was denied that it was an index to evaluate the reproductive function of early cervical cancer, while some literatures showed that LVSI was related to prognosis. Clinical observation showed that conservative surgical treatment of LVSI positive patients should be cautious. Lymphatic vascular interstitial infiltration, which is an independent risk factor for the poor prognosis of cervical cancer, remains controversial as an index to evaluate the reproductive function of early cervical cancer, and it may be related to lymphatic metastasis.
【作者单位】：北京市通州区妇幼保健院妇产科;首都医科大学附属北京朝阳医院妇产科;
【基金】：北京市自然科学基金(7122069) 北京市科学技术委员会科技计划(Z131100004013018) 北京市金桥工程种子资金项目(2014-2016)~~
【分类号】：R737.33

【参考文献】