miRNA-145在不同宫颈组织中的表达意义
发布时间：2018-09-15 19:27
【摘要】：目的探讨miR-145表达在不同宫颈癌组织中的意义。方法应用逆转录聚合酶链反应RT-PCR技术,检测20例正常宫颈组织、20例宫颈鳞状上皮内瘤样病变(cervical intraepithelial neoplasias,CIN)组织及40例宫颈鳞癌(cervical cancer,CC)Ⅱ期中分化组织中miRNA-145表达情况。结果 miR-145的相对表达量在宫颈癌组织中为(0.400±0.242),明显低于CIN组织[(0.742±0.419)],低于正常宫颈组织(1.082±0.478),差异有明显的统计学意义(P0.001)。结论 miR-145的相对表达量在正常宫颈组织、CIN组织、宫颈癌组织中逐渐下降,提示miR-145可能参与宫颈癌发生、发展。
[Abstract]:Objective to investigate the significance of miR-145 expression in different cervical carcinoma tissues. Methods reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of miRNA-145 in 20 cases of normal cervical tissues and 20 cases of cervical squamous intraepithelial neoplasia (cervical intraepithelial neoplasias,CIN) and 40 cases of cervical squamous cell carcinoma (cervical cancer,CC) stage 鈪，
本文编号：2244281
[Abstract]:Objective to investigate the significance of miR-145 expression in different cervical carcinoma tissues. Methods reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of miRNA-145 in 20 cases of normal cervical tissues and 20 cases of cervical squamous intraepithelial neoplasia (cervical intraepithelial neoplasias,CIN) and 40 cases of cervical squamous cell carcinoma (cervical cancer,CC) stage 鈪，
本文编号：2244281
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