1020例外阴上皮内非瘤样病变患者的阴道微生态状况分析

发布时间：2018-09-18 10:11

【摘要】：目的:研究外阴上皮内非瘤样病变与阴道微生态的关系,为外阴上皮内非瘤样病变的诊疗提供线索。方法:收集2012年1月-2017年2月于重庆医科大学附属第二医院妇科门诊就诊,最终活检确诊为外阴上皮内非瘤样病变且有完整资料的患者1020例,回顾性分析其阴道微生态状况。结果:阴道微生态正常者占12.4%(126/1020);阴道微生态失调者占87.6%(894/1020),其中能够明确致病菌诊断者占35.3%(360/1020),其内细菌性阴道病占15.2%(155/1020),外阴阴道假丝酵母菌病占12.2%(124/1020),需氧菌性阴道病占3.0%(31/1020),滴虫性阴道炎占0.7%(7/1020),混合感染占4.2%(43/1020);以细菌性阴道病及外阴阴道假丝酵母菌病多见,明显高于其它阴道炎患者(P0.05);不能检测出明确病原菌,但已存在微生态失调者占52.3%(534/1020)。结论:外阴上皮内非瘤样病变患者的阴道微生态大部分处于失调状态,阴道微生态失衡导致的阴道炎可能与外阴上皮内非瘤样病变的发病有关。
[Abstract]:Objective: to study the relationship between vulvar intraepithelial nonneoplastic lesions and vaginal microecology, and to provide clues for diagnosis and treatment of vulvar intraepithelial nonneoplastic lesions. Methods: from January 2012 to February 2017, 1020 patients with nonneoplastic lesions of vulva and complete data were collected from gynecological outpatient clinic of the second affiliated Hospital of Chongqing Medical University, and their vaginal microecology was analyzed retrospectively. Results: the percentage of normal vaginal microecology was 12.4% (126 / 1020), vaginal microecology disorder was 87.6% (894 / 1020), the diagnosis of pathogenic bacteria was 35.3% (360 / 1020), bacterial vaginosis was 15.2% (155R / 1020), vulvovaginal myceliasis was 12.2% (124r1020), aerobic vaginosis was 3.0% (31r1020), trichomonas vaginalis was 3.0% (31r1020). Sex vaginitis accounted for 0.7% (7 / 1020), mixed infections accounted for 4.2% (43 / 1020), bacterial vaginosis and vulvovaginal candidiasis were common. It was significantly higher than that in other vaginitis (P0.05), but 52.3% (534 / 1020) had microecological disorders. Conclusion: the vaginal microecology of patients with vulvar intraepithelial nonneoplastic lesions is mostly in a maladjusted state. Vaginitis caused by vaginal microecology imbalance may be related to the pathogenesis of vulvar intraepithelial non-tumor-like lesions.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R711.72

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