重组人干扰素α2b阴道泡腾胶囊治疗宫颈人乳头瘤病毒感染的临床研究

发布时间：2018-09-18 10:47

【摘要】：目的评价重组人干扰素α2b阴道泡腾胶囊对宫颈人乳头瘤病毒(HPV)感染的疗效。方法 128例宫颈HPV感染患者随机分为试验组(62例)和对照组(66例)。试验组患者于末次月经干净3 d后,在阴道内放置重组人干扰素α2b阴道泡腾胶囊,每晚1粒,10 d为1个疗程,持续3个疗程。对照组患者予以定期随访观察,未做处理。3个疗程后,比较2组宫颈HPV阴转率、宫颈糜烂程度及不良反应。结果 3个疗程后,试验组HPV-DNA转阴48例,阴转率为77.4%,对照组HPV-DNA自行转阴4例,阴转率为6.1%,试验组阴转率显著高于对照组(P0.05);试验组宫颈糜烂面积缩小者30例,有效率为63.8%(30/47),对照组宫颈糜烂面积缩小者4例,有效率为8.3%(4/48),试验组有效率显著高于对照组(P0.05)。试验组患者无明显不良反应发生。结论重组人干扰素α2b阴道泡腾胶囊对宫颈HPV感染疗效显著,同时可减轻患者宫颈糜烂程度。
[Abstract]:Objective to evaluate the efficacy of recombinant human interferon 伪 2b vaginal effervescent capsule in the treatment of cervical human papillomavirus (HPV) infection. Methods 128 patients with cervical HPV infection were randomly divided into trial group (n = 62) and control group (n = 66). Patients in the test group were treated with recombinant human interferon 伪 2b vaginal effervescent capsule after the last menstruation for 3 days. The patients in the control group were followed up regularly without treatment. After 3 courses of treatment, the negative rate of cervical HPV, the degree of cervical erosion and the adverse reaction were compared between the two groups. Results after three courses of treatment, 48 cases of HPV-DNA turned negative in the trial group, the negative conversion rate was 77.4%, and 4 cases in the control group turned negative spontaneously, the negative conversion rate was 6.1%, the negative conversion rate in the test group was significantly higher than that in the control group (P0.05), 30 cases in the trial group had reduced cervical erosion area. The effective rate was 63.8% (30 / 47). In the control group, the area of cervical erosion was reduced in 4 cases, and the effective rate was 8.3% (4 / 48). The effective rate in the experimental group was significantly higher than that in the control group (P0.05). There was no significant adverse reaction in the trial group. Conclusion Recombinant human interferon 伪 2b vaginal effervescent capsule is effective in the treatment of cervical HPV infection and can reduce the degree of cervical erosion.
【作者单位】：浙江省长兴县妇幼保健院妇产科;福建医科大学附属第一医院妇产科;
【基金】：福建省教育厅科技基金资助项目(JA12145)
【分类号】：R711.74

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