T淋巴细胞亚群在妊娠与复发性自然流产中作用及治疗研究进展
发布时间:2018-10-08 09:02
【摘要】:正胚胎携带父方的MHC单元型,相对于母体犹如同种异体移植,母胎免疫耐受是妊娠建立与维持的前提,机体免疫系统在其中发挥着复杂而精细的调控作用。T淋巴细胞是机体免疫调节的主体,主要包括辅助性T淋巴细胞(Th cell)及调节性T淋巴细胞(Treg),在抵御外界病原体感染、维持机体内环境稳定过程中发挥着重要作用。随着生殖免疫学研究的不断深入,已证实不同T淋巴细胞亚群在诱导
[Abstract]:Compared with the maternal allograft, the maternal and fetal immune tolerance is the prerequisite for the establishment and maintenance of pregnancy. The immune system plays a complex and delicate regulatory role. T lymphocytes are the main body of immune regulation, including helper T lymphocyte (Th cell) and regulatory T lymphocyte (Treg), to resist the infection of external pathogens. It plays an important role in maintaining the stability of the internal environment. With the development of reproductive immunology, it has been proved that different T lymphocyte subsets are induced by different T lymphocyte subsets.
【作者单位】: 山东省肿瘤医院;山东省医学科学院基础医学研究所肿瘤免疫与中药免疫重点实验室;
【基金】:国家自然科学基金项目(No.81373670) 山东省自主创新成果转化专项(2013ZHZX2A0405) 山东省科技发展计划项目(No.2012GSF11840) 山东省自然科学基金项目(No.ZR2010HQ066) 山东省计生委项目[No.[2014]814 山东省中管局项目(2013-216,2013-218] 济南市科技明星计划项目(济科合字2012)
【分类号】:R714.21
[Abstract]:Compared with the maternal allograft, the maternal and fetal immune tolerance is the prerequisite for the establishment and maintenance of pregnancy. The immune system plays a complex and delicate regulatory role. T lymphocytes are the main body of immune regulation, including helper T lymphocyte (Th cell) and regulatory T lymphocyte (Treg), to resist the infection of external pathogens. It plays an important role in maintaining the stability of the internal environment. With the development of reproductive immunology, it has been proved that different T lymphocyte subsets are induced by different T lymphocyte subsets.
【作者单位】: 山东省肿瘤医院;山东省医学科学院基础医学研究所肿瘤免疫与中药免疫重点实验室;
【基金】:国家自然科学基金项目(No.81373670) 山东省自主创新成果转化专项(2013ZHZX2A0405) 山东省科技发展计划项目(No.2012GSF11840) 山东省自然科学基金项目(No.ZR2010HQ066) 山东省计生委项目[No.[2014]814 山东省中管局项目(2013-216,2013-218] 济南市科技明星计划项目(济科合字2012)
【分类号】:R714.21
【参考文献】
相关期刊论文 前10条
1 许园园;刘雨生;;原因不明性复发性流产患者主动免疫治疗效果及调节性T细胞水平变化观察[J];安徽医学;2009年10期
2 曹颖平;张e,
本文编号:2256194
本文链接:https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2256194.html
最近更新
教材专著