四川地区HPV亚型及多重感染与宫颈癌前病变的关系初探
发布时间：2018-10-08 07:52
【摘要】：目的检测四川地区HPV不同亚型及多重感染在不同宫颈病变中的感染情况,评价多重感染与宫颈癌前病变〔宫颈上皮内瘤变(CIN)〕的关系。方法回顾分析2006年6月至2012年5月在我院门诊就诊的1 226例宫颈病变患者(均有病理活检结果),采用PCR-反向点杂交法检测HPV 23种亚型均为阳性结果,分为宫颈炎组、宫颈湿疣组、CINⅠ组、CINⅡ组、CINⅢ组进行分层分析。结果1宫颈炎组、宫颈湿疣组、CINⅠ组分别与CINⅡ、CINⅢ组相比较,低危型HPV构成比增加(P0.01),高危型HPV构成比降低(P0.05)。2宫颈湿疣组低危型HPV感染主要为HPV6、HPV11,其他4组主要为HPV42、HPV43。3高危型HPV感染前4位为HPV58、HPV16、HPV52、HPV18,宫颈炎组HPV16型的构成比(11.0%)低于CINⅡ(20.3%)和CINⅢ组(20.2%)(P0.01),HPV58型的构成比(15.9%)低于CINⅡ组(21.4%)(P0.05)。4宫颈湿疣组HPV多重感染率(68.8%)高于宫颈炎组(23.1%)、CINⅠ组(26.1%)、CINⅡ组(27.8%)、CINⅢ组(27.1%),差异均有统计学意义(P0.01);而后4组间差异没有统计学意义(P0.05)。结论四川地区HPV病毒感染有一定的地域性特点,各种宫颈病变中低危型主要为HPV42、HPV43,高危型主要为HPV58、HPV16、HPV52、HPV18,病毒的多重感染似乎并不是导致宫颈病变进展的重要因素。
[Abstract]:Objective to detect the infection of different subtypes and multiple infections of HPV in different cervical lesions in Sichuan and to evaluate the relationship between multiple infections and (CIN) in cervical precancerous lesions (cervical intraepithelial neoplasia). Methods from June 2006 to May 2012, 1 226 patients with cervical lesions (all with pathological biopsy results) were retrospectively analyzed. All 23 subtypes of HPV were detected by PCR- reverse dot hybridization and divided into cervicitis group. The cervical condyloma group was divided into two groups: cin 鈪，
本文编号：2255998
[Abstract]:Objective to detect the infection of different subtypes and multiple infections of HPV in different cervical lesions in Sichuan and to evaluate the relationship between multiple infections and (CIN) in cervical precancerous lesions (cervical intraepithelial neoplasia). Methods from June 2006 to May 2012, 1 226 patients with cervical lesions (all with pathological biopsy results) were retrospectively analyzed. All 23 subtypes of HPV were detected by PCR- reverse dot hybridization and divided into cervicitis group. The cervical condyloma group was divided into two groups: cin 鈪，
本文编号：2255998
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