局部晚期宫颈癌细胞中乏氧诱导因子-1α表达及其与预后的关系

发布时间：2018-10-10 11:51

【摘要】：目的观察宫颈鳞癌细胞中乏氧诱导因子-1α(HIF-1α)的表达情况及其与预后的关系。方法通过治疗前检测119例宫颈鳞癌患者HIF-1α的表达情况,并分析阳性、阴性表达组放化疗疗效并研究其与宫颈癌预后的关系。结果 119例中晚期宫颈鳞癌患者中HIF-1α表达阳性者86例(72.3%),表达阴性者33例(27.7%)。Ⅱ、Ⅲ期患者表达阴性者的有效率(94.7%、85.7%)高于表达阳性者(87.8%、75.6%),差异有统计学意义(P=0.032,P=0.041);表达阴性者(89.4%、78.5%)2年局控率高于表达阳性者(75.5%、70.2%),差异有统计学意义(P=0.021、P=0.035);表达阴性者2年生存率(100%、85.7%)高于表达阳性患者(91.2%、72.9%),差异有统计学意义(P=0.034、P=0.041)。结论大部分中晚期宫颈鳞癌细胞HIF-1α表达阳性,对于Ⅱ、Ⅲ期患者HIF-1α表达阳性与不良预后相关。
[Abstract]:Objective to investigate the expression of hypoxia inducible factor-1 伪 (HIF-1 伪) in cervical squamous cell carcinoma and its relationship with prognosis. Methods the expression of HIF-1 伪 was detected in 119 patients with cervical squamous cell carcinoma before treatment. The effect of radiotherapy and chemotherapy in positive and negative expression groups was analyzed and the relationship between the expression of HIF-1 伪 and prognosis of cervical carcinoma was studied. Results among 119 cases of cervical squamous cell carcinoma, 86 (72.3%) were positive for HIF-1 伪 and 33 (27.7%) were negative. The effective rate of the patients with negative expression in stage 鈪，

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