子宫腺肌病恶变9例临床病理分析

发布时间：2018-10-11 12:56

【摘要】：目的分析子宫腺肌病恶变的临床及病理学特点。方法回顾性分析北京大学人民医院9例子宫腺肌病恶变患者的临床特点、病理学特征及诊治预后情况。结果患者平均年龄为(48.7±5.1)岁,7例未绝经。主要临床表现为阴道不规则流血。术前都没有获得诊断。术中冰冻病理发现3例腺肌症恶变。恶变类型是子宫内膜样腺癌8例,透明细胞癌1例。免疫组化7例ER(+),6例PR(+),5例P53(+),4例CD10(+)。FIGO分期8例为ⅠA期,1例为ⅠB期。8例行全面分期手术,1例行全子宫+双侧附件切除术。4例采用铂类为基础的联合化疗,1例口服孕激素。8例患者无瘤生存期(60.9±19.8)个月。1例失访。结论子宫腺肌病恶变患者发病较年轻,Ⅰ期患者多。术前诊断困难,术中冰冻病理有一定价值,需要术后病理确诊。治疗参照子宫内膜腺癌和卵巢上皮癌,预后比较好。
[Abstract]:Objective to analyze the clinical and pathological features of malignant changes of adenomyosis. Methods the clinical features, pathological features, diagnosis and treatment and prognosis of 9 patients with adenomyosis and malignancy in the people's Hospital of Peking University were retrospectively analyzed. Results the average age of the patients was (48.7 卤5.1) years. The main clinical manifestations were irregular vaginal bleeding. No diagnosis was made before the operation. Intraoperative frozen pathology found 3 cases of adenomyosis malignant change. The malignant type was endometrial adenocarcinoma in 8 cases and clear cell carcinoma in 1 case. Immunohistochemical staining 7 cases of ER (), 6 cases of PR (), 5 cases of p53 (), 4 cases of CD10 (). FIGO staging, 8 cases of stage 鈪，

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