人乳头瘤病毒16型E5蛋白在宫颈癌中表达及其作用的研究进展
发布时间：2018-10-12 08:52
【摘要】：宫颈癌是常见的女性恶性肿瘤,其发生发展与HPV的感染密切相关。HPV16是宫颈癌患者中感染率最高的亚型,其编码的早期蛋白E5、E6、E7可刺激宫颈上皮细胞转化成肿瘤细胞。E6、E7蛋白在宫颈癌晚期表达,E5可能在早期表达。E5蛋白的是否表达及其致癌机制与多种因子相关。E5蛋白可作用于细胞生长因子受体通路,下调miRNA196a,并通过与HLAⅠ类分子结合协助感染细胞免疫逃逸,从而促进肿瘤的发生。E5蛋白与E6、E7蛋白协同会发挥更强的致宫颈癌作用。本研究对E5蛋白表达与病毒整合的关系及其对宫颈癌的作用进行了综述。
[Abstract]:Cervical cancer is a common malignant tumor in women, and its occurrence and development are closely related to the infection of HPV. HPV16 is the subtype with the highest infection rate in patients with cervical cancer. Its early protein E5, E6, E7, can stimulate the transformation of cervical epithelial cells into tumor cells. E6 E7 protein is expressed in the late stage of cervical cancer, and E5 may be expressed in the early stage. The expression of E5 protein and its carcinogenic mechanism are related to many factors. For the cell growth factor receptor pathway, MiRNA196a, was down-regulated and the immune escape of infected cells was assisted by binding to HLA class 鈪，
本文编号：2265522
[Abstract]:Cervical cancer is a common malignant tumor in women, and its occurrence and development are closely related to the infection of HPV. HPV16 is the subtype with the highest infection rate in patients with cervical cancer. Its early protein E5, E6, E7, can stimulate the transformation of cervical epithelial cells into tumor cells. E6 E7 protein is expressed in the late stage of cervical cancer, and E5 may be expressed in the early stage. The expression of E5 protein and its carcinogenic mechanism are related to many factors. For the cell growth factor receptor pathway, MiRNA196a, was down-regulated and the immune escape of infected cells was assisted by binding to HLA class 鈪，
本文编号：2265522
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