宫颈癌患者的病原菌分布分析

发布时间：2018-10-12 11:33

【摘要】：目的分析生殖道病原菌感染在人乳头瘤病毒(HPV)高危宫颈癌患者中的分布。方法回顾性分析经病理证实为宫颈癌的355例新发病例,作为试验组,对照组选自同期就诊的慢性宫颈炎的538例患者。2组患者在诊断前均行阴道分泌物病原菌培养及HPV-DNA检测,统计2组患者的病原菌分布及HPV检测结果。结果观察组检出HPV阳性患者214例(60.28%),对照组检出HPV阳性患者226例(42.01%),差异有统计学意义(P0.05)。2组检出最多的均为真菌、革兰氏阴性菌、革兰氏阳性菌,其中白色念珠菌数量最多;病原菌检出率及构成比差异均有统计学意义(P0.05)。2组HPV检测结果相比,差异有统计学意义(P0.05);2组HPV检测阳性患者的病原菌培养结果,差异有统计学意义(P0.05)。结论感染为宫颈癌发生的危险因素,生殖道病原菌感染协同HPV感染增加宫颈癌的发生率。
[Abstract]:Objective to analyze the distribution of reproductive tract pathogens in high risk cervical cancer patients with human papillomavirus (HPV). Methods 355 cases of cervical cancer confirmed by pathology were retrospectively analyzed. 538 cases of chronic cervicitis in the control group and the control group were selected from the same period. All the patients in both groups were treated with vaginal secretion pathogen culture and HPV-DNA detection before diagnosis. The distribution of pathogenic bacteria and the results of HPV detection in the two groups were analyzed. Results there were 214 cases (60.28%) of HPV positive in the observation group and 226 cases (42.01%) in the control group. The difference was statistically significant (P0.05). The most detected fungi were Gram-negative bacteria and Gram-positive bacteria in the two groups, among which Candida albicans were the most. The detection rate and composition ratio of pathogenic bacteria were significantly different (P0.05). Compared with the two groups of HPV detection results, the difference was statistically significant (P0.05); two groups of HPV positive patients with the results of pathogenic bacteria culture, the difference was statistically significant (P0.05). Conclusion infection is the risk factor of cervical cancer. The incidence of cervical cancer is increased by the combination of genital tract pathogens infection and HPV infection.
【作者单位】：兰溪市妇幼保健院妇产科;浙江省妇保医院产科;
【基金】：浙江省医学会临床科研基金资助项目(2011ZYC-A66)
【分类号】：R737.33

【共引文献】