妊娠合并HIV感染30例分娩前后情况以及阻断效果临床分析

发布时间：2018-10-12 18:39

【摘要】：目的:分析妊娠合并人类免疫缺陷病毒(HIV)感染产妇分娩前后情况,以及母婴阻断效果。方法:回顾分析东南大学附属南京市第二医院妇产科2005年3月至2016年10月住院分娩的30例妊娠合并HIV感染患者的临床资料。患者于孕前或孕期采用高效抗逆转录病毒治疗(HAART)。选取同期住院分娩的排除传染性疾病的正常孕妇90例。比较两组的孕期合并症、分娩情况、分娩方式及新生儿情况。监测研究组的阻断效果及新生儿生长发育情况。结果:研究组和对照组的孕期贫血、羊水过少、羊水污染发生率比较,差异均有统计学意义(26.67%vs 13.33%,33.33%vs 15.55%,23.33%vs 6.67%,P0.05)。研究组的剖宫产率高于对照组,差异有统计学意义(93.33%vs 48.89%,P0.05)。两组的新生儿体质量比较,差异有统计学意义[(3045.67±341.69)g vs(3273.44±430.19)g,P0.05];两组的男婴数及1min Apgar评分比较,差异无统计学意义(P0.05)。截稿为止,随访至18月婴儿无一例感染(3例失访),随访的婴儿生长发育情况与同龄婴儿比较,未发现明显异常。结论:合并HIV感染孕妇分娩前后合并症及并发症发生概率相对较高。孕期运用HARRT方案,择期行剖宫产分娩、新生儿预防性使用抗病毒药物及人工喂养是阻断HIV母婴传播的重要措施。
[Abstract]:Objective: to analyze the pregnant women with human immunodeficiency virus (HIV) infection before and after delivery, as well as the effect of maternal and child blocking. Methods: the clinical data of 30 cases of pregnancy complicated with HIV infection in obstetrics and gynecology department of Nanjing second Hospital affiliated to Southeast University from March 2005 to October 2016 were analyzed retrospectively. Patients were treated with highly active antiretroviral therapy for (HAART). Before or during pregnancy. A total of 90 normal pregnant women who were excluded from infectious diseases during the same period of hospital delivery were selected. The complications of pregnancy, delivery, delivery mode and newborn were compared between the two groups. The blocking effect of the study group and the growth and development of the newborn were monitored. Results: the incidence of anemia, oligohydramnios and amniotic fluid pollution in the study group and the control group were significantly different (26.67%vs 13.333.33 vs 15.5523.333.33vs 6.67P0.05). The cesarean section rate in the study group was higher than that in the control group, and the difference was statistically significant (93.33%vs 48.89 vs P05). There was significant difference in neonatal body mass between the two groups [(3045.67 卤341.69) g vs (3273.44 卤430.19) g P 0.05], but there was no significant difference in the number of male infants and the 1min Apgar score between the two groups (P0.05). As of the deadline, no infection was found in the infants of 18 months (3 cases lost), and there was no obvious abnormality in the growth and development of the infants compared with the infants of the same age. Conclusion: the incidence of complications and complications in pregnant women with HIV infection before and after delivery is relatively high. Using HARRT scheme during pregnancy, elective cesarean section delivery, prophylactic use of antiviral drugs and artificial feeding are important measures to block mother-to-child transmission of HIV.
【作者单位】：东南大学附属南京市第二医院妇产科;
【分类号】：R714.251

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