卡前列甲酯栓对减少普通足月阴道分娩患者产后出血的临床疗效
发布时间：2018-10-13 11:08
【摘要】：目的观察米索前列醇、缩宫素鼻喷剂及卡前列甲酯栓对普通足月阴道分娩患者产后出血量的临床疗效及其对雌激素、一氧化氮(NO)及一氧化氮合酶(NOS)的影响。方法收集我院收治的普通足月阴道分娩的患者600例,随机分为A组、B组和C组,每组各200例。A组给予缩宫素鼻喷剂,每喷0.1 mL,每侧鼻孔各2喷,每日2次,B组舌下含化米索前列醇200μg,C组给予卡前列甲酯栓1 mg,塞肛。治疗后,比较3组患者血清中雌二醇(E_2)、NO及NOS水平、出血量,观察3组患者的临床疗效和药物不良反应发生情况。结果治疗后,A组总有效率为76.50%(153/200例),B组为86.00%(172/200例),C组为90.50%(181/200例),C组与A组比较,差异有统计学意义(P0.05)。治疗后,A、B、C组E_2分别为(14.75±2.09),(17.63±2.15),(21.82±3.09)nmol·L~(-1);NO分别为(107.83±11.21),(92.42±10.17),(79.25±9.89)nmol·L~(-1);NOS分别为(25.64±3.11),(22.56±3.05),(19.63±2.28)nmol·L~(-1)(P0.05)。A、B、C组2 h内出血量分别为(712.43±40.85),(632.43±42.77),(580.74±37.64)mL;2~24 h出血量分别为(138.92±17.86),(126.94±12.93),(103.85±11.13)mL(P0.05)。A组药物不良反应有鼻腔刺激反应、鼻出血,药物不良反应发生率为1.50%(3/200例);B组药物不良反应有轻度恶心、呕吐、眩晕,药物不良反应发生率为2.50%(5/200例);C组药物不良反应有腹泻、恶心呕吐,药物不良反应发生率为2.00%(4/200例),差异无统计学意义(P0.05)。结论与米索前列醇、缩宫素鼻喷剂治疗比较,卡前列甲酯栓能够更显著提高普通足月阴道分娩患者血清E_2水平,降低血清NO、NOS水平,减少出血量,且安全性较高。
[Abstract]:Objective to observe the clinical effect of misoprostol, oxytocin nasal spray and carprost methyl ester suppository on postpartum hemorrhage and the effects of misoprostol, oxytocin nasal spray and carprost methyl ester suppository on estrogen, nitric oxide (NO) and nitric oxide synthase (NOS). Methods 600 cases of normal term vaginal delivery in our hospital were randomly divided into three groups: group A, group B and group C. Group A received oxytocin nasal spray with 2 sprays per 0. 1 mL, each side of nostril. Two times a day, group B was given methyl carprost suppository for 1 mg, to plug anus in group C with 200 渭 g of misoprostol. After treatment, the serum levels of estradiol (E _ 2), NO and NOS) and blood loss were compared among the three groups, and the clinical efficacy and adverse drug reactions were observed. Results after treatment, the total effective rate of group A was 76.50% (153 / 200 cases of), B group was 86.00% (172 / 200 cases of), C group was 90.50%) (181% of 200 cases of), C group compared with group A), the difference was statistically significant (P0.05). 娌荤枟鍚，
本文编号：2268398
[Abstract]:Objective to observe the clinical effect of misoprostol, oxytocin nasal spray and carprost methyl ester suppository on postpartum hemorrhage and the effects of misoprostol, oxytocin nasal spray and carprost methyl ester suppository on estrogen, nitric oxide (NO) and nitric oxide synthase (NOS). Methods 600 cases of normal term vaginal delivery in our hospital were randomly divided into three groups: group A, group B and group C. Group A received oxytocin nasal spray with 2 sprays per 0. 1 mL, each side of nostril. Two times a day, group B was given methyl carprost suppository for 1 mg, to plug anus in group C with 200 渭 g of misoprostol. After treatment, the serum levels of estradiol (E _ 2), NO and NOS) and blood loss were compared among the three groups, and the clinical efficacy and adverse drug reactions were observed. Results after treatment, the total effective rate of group A was 76.50% (153 / 200 cases of), B group was 86.00% (172 / 200 cases of), C group was 90.50%) (181% of 200 cases of), C group compared with group A), the difference was statistically significant (P0.05). 娌荤枟鍚，
本文编号：2268398
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