神经生长因子、转化生长因子β1在子宫腺肌病子宫内膜组织中表达及左炔诺孕酮宫内缓释系统对其影响研究

发布时间：2018-10-13 11:24

【摘要】：目的探讨神经生长因子(NGF)、转化生长因子β1(TGF-β1)在子宫腺肌病(AM)子宫内膜组织中的表达及左炔诺孕酮宫内缓释系统(LNG-IUS,曼月乐)对其的影响。方法选择2014年2月至2015年10月在河北医科大学第二医院行子宫全切或病灶切除的AM患者62例,根据视觉模拟评分法(VAS)及LNG-IUS放置史分为痛经组33例、无痛经组16例及曼月乐组13例。选择同期因子宫肌瘤行全子宫切除的无慢性盆腔痛及痛经的患者13例作为对照组。取两组在位内膜及病灶,采用免疫组织化学SP法分别检测在位、异位内膜NGF和TGF-β1蛋白表达水平。结果痛经组内膜NGF和TGF-β1蛋白表达较无痛经组和对照组显著增加(均P0.05),且重度、轻中度痛经者与无痛经者比较差异有统计学意义(均P0.05);痛经组内膜NGF和TGF-β1蛋白表达与VAS评分存在显著正相关性;曼月乐组内膜NGF和TGF-β1蛋白表达较痛经组显著降低(均P0.05)。结论 AM在位、异位内膜中NGF和TGF-β1通过协同高表达,共同参与痛经发生;LNG-IUS抑制AM在位、异位内膜NGF和TGF-β1蛋白表达上调,可能是LNGIUS缓解AM痛经机制之一。
[Abstract]:Objective to investigate the expression of nerve growth factor (NGF), transforming growth factor 尾 1 (TGF- 尾 1) in endometrium of (AM) with adenomyosis and the effect of levonorgestrel intrauterine sustained release system (LNG-IUS, manyue) on it. Methods from February 2014 to October 2015, 62 patients with AM underwent total hysterectomy or focal hysterectomy in the second Hospital of Hebei Medical University. According to the visual analogue score (VAS) and LNG-IUS placement history, 33 patients were divided into dysmenorrhea group (n = 33) and dysmenorrhea group (n = 33). No dysmenorrhea group (n = 16) and Manyue group (n = 13). Thirteen patients without chronic pelvic pain and dysmenorrhea who underwent hysterectomy for hysteromyoma were selected as control group. The expression of NGF and TGF- 尾 1 protein in eutopic and ectopic endometrium were detected by immunohistochemical SP method. Results the expression of NGF and TGF- 尾 1 protein in endometrium of dysmenorrhea group was significantly higher than that of non-dysmenorrhea group and control group (P0.05). There was significant difference between mild and moderate dysmenorrhea group and no dysmenorrhea group (P0.05); the expression of NGF and TGF- 尾 1 protein in endometrium of dysmenorrhea group was positively correlated with VAS score; the expression of NGF and TGF- 尾 1 protein in endometrium of Manyue group was significantly lower than that in dysmenorrhea group (P0.05). Conclusion in ectopic endometrium, NGF and TGF- 尾 1 are involved in dysmenorrhea by co-overexpression of NGF and TGF- 尾 1 in ectopic endometrium, while LNG-IUS inhibits the eutopic AM and up-regulates the expression of NGF and TGF- 尾 1 in ectopic endometrium, which may be one of the mechanisms of LNGIUS in relieving dysmenorrhea of AM.
【作者单位】：河北医科大学第二医院妇产科;
【分类号】：R711.71

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