Tei指数评估妊娠期糖尿病胎儿及出生后新生儿、婴儿整体心功能研究

发布时间：2018-10-14 12:34

【摘要】：目的:应用Tei指数探讨母体高血糖环境对胎儿及其出生后整体心功能的影响。方法:选取孕28~41+6周胎儿205例(正常组120例,妊娠期糖尿病组85例),足月产1~7天新生儿90例(正常组30例,血糖控制良好组30例,血糖控制不良组30例),足月产2~3个月婴儿75例(正常组30例,血糖控制良好组25例,血糖控制不良组20例)。测量左、右心室Tei指数。结果:与正常妊娠组(左室:0.41±0.17、右室:0.41±0.16)比较,血糖控制良好组胎儿的心室Tei指数(左室:0.44±0.12,右室:0.44±0.11)无差异(P0.05),血糖控制不良组(左室:0.50±0.17,右室:0.50±0.10)均增高(P0.05)。与正常新生儿组(左室:0.40±0.14,右室:0.26±0.11)比较,血糖控制良好组(左室:0.43±0.13,右室:0.28±0.14)无差异(P0.05),血糖控制不良组(左室:0.46±0.16,右室:0.31±0.12)均增高(P0.05)。与正常婴儿组(左室:0.39±0.13,右室:0.25±0.14)比较,血糖控制良好组(左室:0.40±0.12,右室:0.25±0.17)无差异(P0.05),血糖控制不良组(左室:0.43±0.16,右室:0.29±0.12)稍高,差异有统计学意义(P0.05)。结论:GDM血糖控制不良胎儿心功能受损,新生儿、婴儿心功能仍低于正常水平。
[Abstract]:Objective: to investigate the effect of maternal hyperglycemia on fetal and postnatal cardiac function by Tei index. Methods: 205 fetuses (120 normal, 85 gestational diabetes) and 90 newborns (30 normal and 30 well controlled) were selected. There were 30 cases in poor blood glucose control group, 75 cases in term birth 2 ~ 3 months group (30 cases in normal group, 25 cases in good blood glucose control group and 20 cases in poor blood glucose control group). Tei index of left and right ventricle was measured. Results: compared with the normal pregnancy group (left ventricular: 0.41 卤0.17, right ventricle: 0.41 卤0.16), the ventricular Tei index (left ventricular: 0.44 卤0.12, right ventricle: 0.44 卤0.11) of the fetus with good blood glucose control group had no difference (P0.05), while that of the poor blood glucose control group (left ventricle: 0.50 卤0.17, right ventricle: 0.50 卤0.10) was higher (P0.05). Compared with the normal neonates group (left ventricular: 0.40 卤0.14, right ventricle: 0.26 卤0.11), there was no difference between the two groups (left ventricle: 0.43 卤0.13, right ventricle: 0.28 卤0.14) (P0.05), but the blood glucose control group (left ventricle: 0.46 卤0.16, right ventricle: 0.31 卤0.12) were higher than those in the control group (P0.05). Compared with normal infant group (left ventricular: 0.39 卤0.13, right ventricle: 0.25 卤0.14), there was no significant difference in blood glucose control group (left ventricle: 0.40 卤0.12, right ventricle: 0.25 卤0.17) (P0.05), but poor blood glucose control group (left ventricle: 0.43 卤0.16, right ventricle: 0.29 卤0.12), the difference was statistically significant (P0.05). Conclusion: the fetal heart function of GDM is impaired and the heart function of the newborn is still lower than the normal level.
【作者单位】：漯河医学高等专科学校第一附属医院漯河市中心医院妇产科;漯河医学高等专科学校药理教研室;漯河医学高等专科学校第一附属医院漯河市中心医院超声科;
【基金】：漯河医学高等专科学校2013年度科研计划项目(No:2013-S-LMC12)
【分类号】：R714.256

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