卵巢癌患者并发静脉血栓形成的危险因素及预后研究

发布时间：2018-10-14 15:22

【摘要】：目的探讨卵巢癌患者发生静脉血栓形成(VTE)的高危因素,以及合并VTE对生存时间的影响。方法收集郑州大学第二附属医院自2010年7月至2014年7月共25例卵巢癌发生VTE患者的临床资料,并选取同期未发生血栓事件的卵巢癌患者50例作为对照组,对两组患者的临床参数,包括年龄、体重指数(BMI)、高血压、糖尿病、高脂血症、CA125水平、国际妇产科联盟(FIGO)分期和分级、组织学类型、化疗和生存数据进行分析和比较。结果在对血栓组和非血栓组的单因素分析中,CA125水平(Z=-1.978,P=0.048)、晚期癌(χ2=4.653,P=0.031)、透明细胞癌(χ2=8.248,P=0.049)和高脂血症(χ2=4.807,P=0.028)是发生VTE的潜在危险因素。在多因素分析中,晚期癌和高脂血症为VTE的独立危险因素,OR值分别为10.836(95%CI 1.807~108.025,P=0.042)、4.421(95%CI 1.173~16.658,P=0.028)。血栓组25例中,没有出现因VTE直接导致死亡的事件,但血栓组的中位生存时间为41.0(4~43)个月,非血栓组的中位生存时间为55.0(1~60)个月,两组的生存时间差异有统计学意义(P=0.004)。结论卵巢癌患者发生VTE的风险高,应及时进行危险因素评估并对高危患者在围手术期和化疗期间积极采取预防性措施,以减少VTE的发生。
[Abstract]:Objective to investigate the risk factors of (VTE) in patients with ovarian cancer and the influence of VTE on survival time. Methods from July 2010 to July 2014, 25 ovarian cancer patients with VTE were collected from the second affiliated Hospital of Zhengzhou University, and 50 patients with ovarian cancer who had no thrombotic events were selected as the control group. The clinical parameters including age, body mass index (BMI),) hypertension, diabetes mellitus, hyperlipidemia, CA125 level, (FIGO) staging and grading, histological type, chemotherapy and survival data of the two groups were analyzed and compared. Results in univariate analysis of thrombus group and non-thrombus group, the levels of CA125 (Z-1.978 P0. 048), advanced carcinoma (蠂 2 + 4. 653), clear cell carcinoma (蠂 2 + 8. 248% P0. 049) and hyperlipidemia (蠂 2 + 4. 807 P0. 028) were the potential risk factors for the development of VTE. In multivariate analysis, advanced cancer and hyperlipidemia were independent risk factors for VTE. The OR values were 10.836 (95%CI 1.807, 108.025, P0. 042) and 4.421 (95%CI 1. 173, 16. 658, P0. 028, respectively). There was no death due to VTE in 25 cases of thrombus group, but the median survival time of thrombus group was 41.0 (4 / 43) months, and the median survival time of non-thrombus group was 55.0 (1 / 60) months. The difference between the two groups was statistically significant (P0. 004). Conclusion the risk of VTE in patients with ovarian cancer is high. The risk factors should be evaluated in time and preventive measures should be taken to reduce the incidence of VTE in perioperative and chemotherapy period.
【作者单位】：郑州大学第二附属医院妇产科;
【分类号】：R737.33;R543.6

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