人乳头状瘤病毒基因分型与宫颈非典型腺细胞检测的临床研究
发布时间：2018-10-14 20:05
【摘要】：目的了解宫颈存在非典型腺细胞时人乳头状瘤病毒(HPV)感染和基因分布,为进一步诊断和判断预后提供依据。方法回顾性分析2012年4月-2013年3月因宫颈存在非典型腺细胞的53例妇女为观察组,平均年龄57岁;宫颈无上皮内病变或恶性病变的338名妇女为对照组,平均年龄62岁,所有研究对象均进行宫颈液基细胞检测(TCT)、HPV-DNA分型。结果观察组有34.0%感染≥1种高危型HPV(HR-HPV),HPV-16和(或)HPV-18感染率为20.8%,与对照组比较,差异有统计学意义(P0.05);观察组单一HPV亚型感染率为40.0%、多重HPV亚型感染率为9.5%、多重HR-HPV感染率为5.7%,以单一HPV亚型感染更为常见,差异有统计学意义(P0.05);两组间低危型HPV(LR-HPV)感染率比较为13.2%与17.2%,差异无统计学意义。结论宫颈存在非典型腺细胞时有较高的HR-HPV感染率,HR-HPV基因检测及分型对宫颈存在非典型腺细胞的预后判断、疗效监测等具有重要价值。
[Abstract]:Objective to investigate the (HPV) infection and gene distribution of human papillomavirus (HPV) in the presence of atypical adenocytes in the cervix, so as to provide evidence for further diagnosis and prognosis. Methods A retrospective analysis of 53 women with atypical glandular cells in the cervix from April 2012 to March 2013 was performed, with an average age of 57 years, and 338 women with no intraepithelial or malignant cervical lesions as control group, with an average age of 62 years. All subjects were tested for (TCT), HPV-DNA typing by cervical fluid-based cells. Results in the observation group, 34.0% of the patients were infected with more than one high-risk type of HPV (HR-HPV), and the infection rate of HPV-16 and / or HPV-18 was 20.8%, compared with the control group. The infection rate of single HPV subtype was 40.0 in the observation group, 9.5in the multiple HPV subtype, 5.7 in the multiple HR-HPV infection rate, especially in the single HPV subtype infection. The infection rate of low risk HPV (LR-HPV) between the two groups was 13. 2% and 17. 2% respectively. There was no significant difference between the two groups. Conclusion there is a high rate of HR-HPV infection in the presence of atypical glandular cells in the cervix. The detection and typing of HR-HPV gene is of great value for the prognosis of atypical glandular cells in the cervix and the monitoring of the curative effect.
【作者单位】： 东阳市人民医院病理科;东阳市人民医院检验科;东阳市人民医院肿瘤中心;
【基金】：浙江省科技厅重点创新团队基金项目(2012R10046-06)
【分类号】：R737.33
[Abstract]:Objective to investigate the (HPV) infection and gene distribution of human papillomavirus (HPV) in the presence of atypical adenocytes in the cervix, so as to provide evidence for further diagnosis and prognosis. Methods A retrospective analysis of 53 women with atypical glandular cells in the cervix from April 2012 to March 2013 was performed, with an average age of 57 years, and 338 women with no intraepithelial or malignant cervical lesions as control group, with an average age of 62 years. All subjects were tested for (TCT), HPV-DNA typing by cervical fluid-based cells. Results in the observation group, 34.0% of the patients were infected with more than one high-risk type of HPV (HR-HPV), and the infection rate of HPV-16 and / or HPV-18 was 20.8%, compared with the control group. The infection rate of single HPV subtype was 40.0 in the observation group, 9.5in the multiple HPV subtype, 5.7 in the multiple HR-HPV infection rate, especially in the single HPV subtype infection. The infection rate of low risk HPV (LR-HPV) between the two groups was 13. 2% and 17. 2% respectively. There was no significant difference between the two groups. Conclusion there is a high rate of HR-HPV infection in the presence of atypical glandular cells in the cervix. The detection and typing of HR-HPV gene is of great value for the prognosis of atypical glandular cells in the cervix and the monitoring of the curative effect.
【作者单位】： 东阳市人民医院病理科;东阳市人民医院检验科;东阳市人民医院肿瘤中心;
【基金】：浙江省科技厅重点创新团队基金项目(2012R10046-06)
【分类号】：R737.33
【二级参考文献】
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1 郑华生;郑迪楠;李剑民;林e，
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