年轻患者子宫内膜癌组织中ER、PR、P53病理表达情况及其临床意义

发布时间：2018-10-15 13:36

【摘要】：目的探讨年轻子宫内膜癌患者临床资料及组织中ER、PR、P53病理表达情况及其临床意义。方法选取郑州大学第二附属医院子宫内膜癌患者,以年龄45岁为界分为A、B两组,回顾性分析其临床病理资料。结果与年龄≥45岁子宫内膜癌患者比,年龄45岁内膜癌患者孕次及产次、是否有合并症、组织学分级、肌层浸润深度、PR阳性率及P53阳性率差异有统计学意义(P0.05)。ER,PR表达与年龄呈负相关,P53阳性表达与组织学分级呈正相关(r=0.289,P0.05),与肌层浸润深度呈负相关(r=-0.345,P0.05)。结论 (1)年轻子宫内膜癌患者应加强子宫内膜监控及自身健康管理;(2)年轻患者子宫内膜癌组织中ER、PR表达较高,为其选择激素治疗可行性提供证据支持;(3)年轻患者子宫内膜癌组织中P53阳性表达率低,P53阳性表达与内膜癌组织学分级、肌层浸润深度相关,可作为推断预后的指标。
[Abstract]:Objective to investigate the clinical data and pathological expression of ER,PR,P53 in young endometrial carcinoma patients and its clinical significance. Methods the patients with endometrial carcinoma in the second affiliated Hospital of Zhengzhou University were divided into two groups according to their age of 45 years. The clinicopathological data were analyzed retrospectively. Results compared with the patients with endometrial carcinoma aged more than 45 years, whether there were complications and histological grades in the pregnancy and delivery of the patients with endometrial cancer aged 45 years or older. The depth of myometrial invasion, the positive rate of PR and the positive rate of p53 were significantly different (P0.05). The expression of ER,PR was negatively correlated with age, positive expression of p53 was positively correlated with histological grade (r = 0.289 P 0.05), and negatively correlated with depth of myometrium invasion (P 0.05). Conclusion (1) the young patients with endometrial carcinoma should strengthen the monitoring of endometrium and their own health management, and (2) the expression of ER,PR is higher in the young patients with endometrial carcinoma. (3) the positive expression rate of p53 in endometrial carcinoma was low, and the positive expression of p53 was correlated with histological grade and depth of myometrium invasion, which could be used as a prognostic index.
【作者单位】：郑州大学第二附属医院妇产科;
【基金】：河南省基础与前沿技术研究计划项目(No:122300410409)
【分类号】：R737.33

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