补肾活血法治疗肾虚血瘀型围绝经期综合征及对心脏变时功能影响的临床研究

发布时间：2018-10-15 20:10

【摘要】：目的：通过观察补肾活血法治疗肾虚血瘀型围绝经期综合征的临床疗效及对心脏变时功能的影响，观察治疗前后患者临床症状、内分泌激素水平、血脂水平及心脏变时功能改善情况，进而揭示补肾活血法对肾虚血瘀型围绝经期综合征的临床疗效及对心脏变时功能的影响。方法：将60例肾虚血瘀型围绝经期综合征心脏变时功能不良的患者随机分为观察组(服用导师自拟补肾活血丸)、对照组(服用芬吗通)，观察治疗前后临床症状、体征、内分泌激素指标、血脂指标、心脏变时功能指标的改善情况。结果：临床观察结果显示，补肾活血法治疗肾虚血瘀型围绝经期综合征的综合疗效、改善中医证候疗效、Kupperman积分、改善烘热汗出，腰膝酸软，头晕耳鸣，烦躁易怒，，失眠多梦，阴道干涩中医症候单项方面都是有效的，与对照组相比无明显差异（P0.05），在改善肢体麻木疼痛，肌肤甲错，口干不欲饮的中医症候单项方面与对照组相比有明显优势(P0.05)，其对血清生殖内分泌激素、血脂、心脏变时功能的改善是有效的，与对照组相比无明显差异(P0.05)，且观察组疗效不受年龄、病程、病情程度的影响，观察组药物不良反应少，安全性好。结论：补肾活血法治疗肾虚血瘀型围绝经期综合征有较好的临床疗效，通过对内分泌激素水平、血脂水平的调节，可以对心脏变时功能有较好的改善作用。补肾活血法通过改善患者下丘脑－垂体－卵巢轴功能，调节内分泌激素水平，反馈抑制FSH的分泌，调节血脂代谢，改善心脏变时功能，从而达到治疗肾虚血瘀型围绝经期综合征以及预防心血管疾病发生的目的。
[Abstract]:Objective: to observe the clinical effect of tonifying kidney and activating blood circulation method in treating peri-menopausal syndrome of kidney deficiency and blood stasis and its influence on heart function, and to observe the clinical symptoms and endocrine hormone levels before and after treatment. The level of blood lipids and the improvement of heart function were improved, and the clinical effect of Bushen Huoxue method on the peri-menopausal syndrome of kidney deficiency and blood stasis type and the influence of Bushen Huoxue method on the function of cardiac chronotropy were revealed. Methods: sixty patients with peri-menopausal syndrome with kidney deficiency and blood stasis were randomly divided into observation group (taking tutors' self-made Bushen Huoxue Pill) and control group (taking Fenmuotong). The clinical symptoms and signs were observed before and after treatment. The improvement of endocrine hormone index, blood lipid index and cardiac function index. Results: the clinical observation results showed that the comprehensive curative effect of tonifying kidney and activating blood circulation in treating peri-menopausal syndrome of kidney deficiency and blood stasis type, improving the curative effect of TCM syndromes, Kupperman integral, improving heat sweating, sore waist and knee, dizziness and tinnitus, irritability and irritability, insomnia and many dreams, Vagina dry astringent Chinese medicine symptom single aspect is effective, compared with the control group has no obvious difference (P0.05), in the improvement limb numbness pain, the skin is wrong, Compared with the control group, the single aspect of TCM syndromes which do not want to drink is superior to the control group (P0.05). It is effective to improve the serum reproductive endocrine hormone, blood lipid and heart function. Compared with the control group, there was no significant difference (P0.05), and the effect of the observation group was not affected by age, course of disease and severity of the disease. The observation group had fewer adverse drug reactions and better safety. Conclusion: the therapy of tonifying the kidney and activating blood circulation has a better clinical effect on the peri-menopausal syndrome of kidney deficiency and blood stasis. By regulating the levels of endocrine hormones and blood lipids, it can improve the function of the heart. Bushen Huoxue method can improve the function of hypothalamus-pituitary-ovary axis, regulate the level of endocrine hormone, inhibit the secretion of FSH, regulate the metabolism of blood lipid, and improve the function of heart. In order to achieve the treatment of kidney deficiency and blood stasis type perimenopausal syndrome and prevent cardiovascular disease.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.75

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