三种促排卵方案用于卵巢低反应助孕患者效果比较

发布时间：2018-10-16 10:04

【摘要】：目的探讨卵巢低反应患者体外受精—胚胎移植(IVF-ET)中最理想的促排卵方案。方法将322例行IVF-ET助孕的卵巢低反应患者分为三组,微刺激组108例采用微刺激方案治疗,短方案组62例采用短方案治疗,超短方案组152例采用超短方案治疗,比较三组周期取消率、总促性腺激素释放激素(Gn)应用天数(Gn天数)、人绒毛膜促性腺激素(HCG)日子宫内膜厚度、血雌二醇(E2)、促黄体生成素(LH)、孕酮(P)水平、平均获卵数、成胚率、优胚率、生化妊娠率、临床妊娠率。结果微刺激组周期取消率明显高于其余两组(P均0.05);微刺激组总Gn天数最短,超短方案组总Gn天数最长(P0.05);微刺激组HCG日子宫内膜厚度低于其他两组,但差异无统计学意义;微刺激组HCG日E2水平、平均获卵数均低于另两组,超短方案组HCG日LH水平低于另两组,P均0.05;三组成胚率、优胚率、生化妊娠率、临床妊娠率均无统计学差异。结论超短方案是较理想的卵巢低反应促排卵方案。
[Abstract]:Objective to investigate the optimal ovulation promotion protocol in vitro fertilization and embryo transfer (IVF-ET) in patients with low ovarian response. Methods the patients with ovarian hyporesponse were divided into three groups: microstimulation group (n = 108), short regimen group (n = 62) and ultrashort regimen group (n = 152). The rate of cycle cancellation, the days of total gonadotropin releasing hormone (Gn) application (Gn), the thickness of endometrium on the day of (HCG), serum estradiol (E2), (LH), progesterone (P) level, the average number of eggs obtained and the rate of embryo formation were compared among the three groups. Excellent embryo rate, biochemical pregnancy rate, clinical pregnancy rate. Results the rate of cycle cancellation in the micro-stimulation group was significantly higher than that in the other two groups (P 0.05), the days of total Gn in the micro-stimulation group were the shortest, the total Gn days in the ultra-short group were the longest (P0.05), the endometrial thickness in the micro-stimulation group was lower than that in the other two groups, but the difference was not statistically significant. The level of E _ 2 on HCG day, the average number of eggs obtained in the microstimulation group were lower than those in the other two groups, and the LH level on the day of HCG in the ultrashort group was lower than that in the other two groups (P < 0.05). There was no statistical difference in the rate of three-component embryo, the rate of excellent embryo, the rate of biochemical pregnancy and the rate of clinical pregnancy. Conclusion the ultrashort regimen is an ideal low-response ovulatory regimen for ovulation.
【作者单位】：青岛大学医学院附属医院;
【分类号】：R714.8

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