女性生殖道癌肉瘤12例临床分析

发布时间：2018-10-18 19:13

【摘要】：目的：癌肉瘤(carcino sarcomas,CS)又被命名为:恶性混合性中胚叶肿瘤，也称为恶性混合性苗勒氏管肿瘤、肉瘤样癌，是由恶性间叶成分和恶性上皮成分组成的混合性肿瘤。它是一种罕见的高度恶性肿瘤，可发生于食管、乳腺、肝、喉、肺、肾、膀胱、前列腺等处。子宫癌肉瘤是女性生殖系统癌肉瘤中最为常见的类型，在子宫体恶性肿瘤中约占2%~5%，在卵巢恶性肿瘤中占不到1%，发生于宫颈和输卵管的癌肉瘤则更为罕见。有报道指出，癌肉瘤的预后一般较差，5年生存率在20%~30%之间，目前尚没有统一、有效的治疗方案，寻求更有效的治疗方案是改善预后的关键。本课题分析了12例就诊于河北医科大学第二医院妇科的生殖道癌肉瘤患者，旨在总结女性生殖道癌肉瘤的临床特点、影像学特点、病理及免疫组化特点、治疗方案、影响预后的相关因素，为女性生殖道癌肉瘤的早期诊断及改善预后提供参考。方法：对2003--2013年于河北医科大学第二医院妇科诊治生殖道癌肉瘤病人12例回顾性总结分析女性生殖道癌肉瘤的临床特点、影像学特点、病理及免疫组化特点、治疗方案、影响预后的相关因素。结果：本组子宫癌肉瘤5例，，卵巢癌肉瘤7例，其中I期2例、II期2例、III期6例、IV期2例。死亡4例的生存期分别是4、5、10、25个月。8例存活的生存期分别是48、40、36、28、24、15、6、4个月。结论：女性生殖道癌肉瘤是一种恶性程度极高、侵袭性极强的肿瘤，治疗应采取以根治性手术为主并结合辅助放、化疗的综合性、个体化治疗，但其临床进展迅速，预后极差。
[Abstract]:Objective: carcinosarcoma (carcino sarcomas,CS) is also named as malignant mixed mesodermal tumor, also known as malignant mixed mullerian duct tumor. Sarcomatoid carcinoma is a mixed tumor composed of malignant mesenchymal components and malignant epithelial components. It is a rare, highly malignant tumor that can occur in the esophagus, mammary gland, liver, larynx, lung, kidney, bladder, prostate, etc. Uterine carcinosarcoma is the most common type in female reproductive system carcinosarcoma, accounting for about 2% of uterine body malignant tumors, less than 1 in ovarian malignant tumors, and more rare in cervix and fallopian tube carcinosarcoma. It has been reported that the prognosis of carcinosarcoma is generally poor. The 5-year survival rate is between 20% and 30%. There is no uniform and effective treatment plan. Seeking more effective treatment is the key to improve the prognosis. Twelve patients with genital tract carcinosarcoma in the second Hospital of Hebei Medical University were analyzed in this paper. The purpose of this study was to summarize the clinical, imaging, pathological and immunohistochemical features of female genital tract carcinosarcoma. The related prognostic factors provide reference for early diagnosis and improvement of prognosis of female genital tract carcinosarcoma. Methods: twelve cases of gynecological diagnosis and treatment of female genital tract carcinosarcoma from 2003 to 2013 in the second Hospital of Hebei Medical University were retrospectively analyzed. Factors related to prognosis. Results: there were 5 cases of uterine carcinosarcoma and 7 cases of ovarian cancer sarcoma, including 2 cases of stage I, 2 cases of II, 6 cases of III and 2 cases of IV. The survival time of 4 dead cases was 10 and 25 months, respectively, and the survival time of 8 patients was 48 ~ 4036 ~ 2824 ~ 15 ~ (15) months, respectively. Conclusion: female genital tract carcinosarcoma is a highly malignant and aggressive tumor. Radical surgery should be taken as the main treatment, combined with adjuvant radiotherapy and chemotherapy, individualized treatment, but its clinical progress is rapid and the prognosis is very poor.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.3

【引证文献】