抗菌药物预防使用时机对剖宫产患者术后感染的影响

发布时间：2018-10-21 10:52

【摘要】：目的:探讨抗菌药物预防使用时机对剖宫产患者术后感染的影响。方法:选择择期行剖宫产患者100例,按随机数字表法分为观察组和对照组,各50例。两组患者均择期行剖宫产术。对照组患者于胎儿断脐后立即给予注射用头孢硫脒2.0 g,静脉注射,术后6 h内再给予2.0 g,静脉注射;观察组患者切皮前0.5~2 h给予注射用头孢硫脒2.0 g,静脉注射,术后6 h内再给予2.0g,静脉注射。比较两组患者手术时间、术中失血量、抗菌药物预防应用时间及术后6、12、24、48 h体温,术后48 h白细胞、中性粒细胞水平,以及术后子宫内膜炎、切口感染、尿路感染、产褥病等并发症的发生率。结果:两组患者手术时间、术中失血量及术后6、12、24、48 h体温,术后48 h白细胞、中性粒细胞水平比较,差异均无统计学意义(P0.05);对照组患者抗菌药物预防应用时间[(4.8±1.60)h]明显短于观察组[(5.5±1.65)h],差异有统计学意义(P0.05)。两组患者术后子宫内膜炎(0 vs.2.00%)、伤口感染(0 vs.0)、尿路感染(2.00%vs.2.00%)、产褥病(4.00%vs.6.00%)发生率比较,差异均无统计学意义(P0.05)。结论:切皮前和断脐后使用抗菌药物对剖宫产患者术后感染预防效果相当,但切皮前用药延长了抗菌药物预防时间。
[Abstract]:Objective: to investigate the influence of the time of prophylactic use of antibiotics on postoperative infection in patients with cesarean section. Methods: 100 patients with cesarean section were randomly divided into observation group and control group. Cesarean section was performed in both groups. The patients in the control group were given Cefathiform 2.0 g immediately after the fetal umbilical cord was cut, and the patients in the observation group were given cefathiamidine 2.0 g intravenously within 6 hours after operation, and the patients in the observation group were given Cefathiamidine 2.0 g for injection 2 hours before skin incision. 2. 0 g was injected intravenously within 6 hours after operation. The time of operation, the amount of blood lost during operation, the time of prophylactic use of antimicrobial agents, the body temperature of 6121224 hours after operation, the levels of leukocytes and neutrophils at 48 hours after operation, and endometritis, incision infection and urinary tract infection were compared between the two groups. Incidence of complications such as puerperal disease. Results: the time of operation, the amount of blood loss during operation, the body temperature of 612o 24 hours after operation, the level of white blood cells and neutrophils at 48 hours after operation were compared between the two groups. There was no significant difference (P0.05); the time of prophylactic use of antimicrobial agents in the control group [(4.8 卤1.60) h] was significantly shorter than that in the observation group [(5.5 卤1.65) h], the difference was statistically significant (P0.05). There was no significant difference in the incidence of endometritis (0 vs.2.00%), wound infection (0 vs.0), urinary tract infection (2. 00 vs 2. 00%) and puerperal disease (4. 00 vs 6. 00%) between the two groups (P0.05). Conclusion: the prophylactic effect of antimicrobial agents before incision and after amputation of umbilical cord on postoperative infection prevention of cesarean section patients is equal, but the prophylactic time of antimicrobial drugs is prolonged before skin incision.
【作者单位】：南充市中心医院/川北医学院第二临床医学院;
【基金】：四川省基层卫生事业发展研究中心重点项目(No.SJWF1401)
【分类号】：R719.8

【相似文献】