选择性卵裂期单胚胎移植的妊娠分娩结局

发布时间：2018-10-21 12:13

【摘要】：目的比较选择性卵裂期单个优质胚胎移植与双优质胚胎移植的妊娠分娩结局。方法回顾性分析2014年1月~2015年10月在广州市妇女儿童医疗中心生殖医学中心实施体外受精胚胎移植治疗年轻患者239例,选择单个卵裂期优质胚胎进行移植的年轻患者39例为研究组,同期移植2个优质胚胎的年轻患者200例对照组。分析比较两组间临床妊娠结局及分娩结局。结果两组平均年龄、体质量指数、基础内分泌、不孕年限、HCG日子宫内膜厚度无统计学差异(P0.05);单胚胎移植组HCG日雌激素水平、获卵数高于双胚胎移植组,总Gn用量低于双胚胎移植组(P0.05);单胚胎移植组胚胎着床率为56.4%,高于双胚胎移植组的37.8%(P0.05);两组临床妊娠率和活产率无统计学差异(56.4%vs 66.0%,48.7%vs 51.5%,P0.05)。单胚胎移植组无1例多胎妊娠,而双胚胎移植组双胎妊娠率为22.7%(P0.05)。单胚胎移植组分娩孕周、新生儿出生体质量明显高于双胚胎移植组(38.7周vs 37.8周,3.3 kg vs 2.9 kg,P0.05);早产率在单胚胎组仅为10.5%,低于双胚胎移植组27.2%,但差异无显著性。单胚胎移植组无1例低体质量儿出生,而双胎组低体质量儿比例占22.6%(P0.05)。结论卵裂期选择性单胚胎移植与双胚胎移植相比,可明显降低双胎率,对活产率无影响,同时可以获得更好的产科结局。
[Abstract]:Objective to compare the pregnancy and parturition outcome of selective cleavage stage single high quality embryo transfer and double high quality embryo transfer. Methods from January 2014 to October 2015, 239 young patients were treated with in vitro fertilization and embryo transfer from January 2014 to October 2015 in the Reproductive Medicine Center of Guangzhou Women and Children Medical Center. 39 young patients with single cleavage stage high quality embryos were selected as study group and 200 young patients with 2 high quality embryos as control group. The clinical pregnancy outcome and delivery outcome were analyzed and compared between the two groups. Results there was no significant difference in average age, body mass index, basal endocrine, length of infertility and endometrial thickness on HCG day between the two groups (P0.05). The level of estrogen in single embryo transfer group on HCG day was higher than that in double embryo transfer group, and the number of eggs in single embryo transfer group was higher than that in double embryo transfer group. The total amount of Gn was lower than that of the double embryo transfer group (P0.05); the embryo implantation rate of the single embryo transfer group was 56.4, which was higher than that of the double embryo transfer group (P 0.05); there was no significant difference between the two groups in clinical pregnancy rate and live birth rate (56.4%vs 66.0% vs 51.5% P 0.05). There was no multiple pregnancy in single embryo transfer group, while the twin pregnancy rate was 22. 7% in double embryo transfer group (P0.05). The birth weight of the single embryo transfer group was significantly higher than that of the double embryo transfer group (38.7 weeks vs 37.8 weeks, 3.3 kg vs 2.9 kg,P0.05), and the preterm delivery rate in the single embryo group was only 10.5, lower than that in the double embryo transfer group, but there was no significant difference. In the single embryo transfer group, there was not a case of low body weight infant born, while the proportion of the twin group was 22. 6% (P0.05). Conclusion selective single embryo transfer in cleavage stage can significantly reduce the rate of twin embryos, have no effect on the live delivery rate, and obtain a better obstetrical outcome.
【作者单位】：广州市妇女儿童医疗中心生殖医学中心;
【基金】：广东省计生委基金(2012319)
【分类号】：R714.8

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