稽留流产的胎儿绒毛染色体异常及相关因素分析
发布时间：2018-10-21 19:02
【摘要】：目的:探讨稽留流产的胚胎绒毛染色体异常与口服叶酸、年龄、胚胎孕周及流产次数的关系。方法:收集稽留流产的胚胎绒毛组织82例,采用新一代基因测序(NGS)技术检测胚胎绒毛染色体,分析口服叶酸、年龄、胚胎孕周、流产次数与染色体异常的关系。结果:82例稽留流产的胚胎绒毛染色体中,46例(56.10%,46/82)异常,其中数目异常38例(82.61%,38/46),结构异常8例(17.39%,8/46),三体发生率89.47%(34/38)。82例胚胎绒毛染色体中,排除胚胎孕周等因素对年龄的影响,选择25~39岁孕妇的胚胎绒毛染色共74例,其中染色体异常率62.16%(46/74),35~39岁孕妇的染色体异常率(43.48%,20/46)高于30~34岁(23.91%,11/46)、25~30岁(32.61%,15/46),差异有统计学意义(P0.05),30~35岁孕妇的染色体异常率与25~30岁孕妇比较,差异无统计学意义(P0.05)。82例胚胎绒毛染色体中,排除年龄等因素对胚胎孕周的影响,胚胎停育孕周8~12周共78例,染色体异常率55.13%(43/78),胚胎停育孕周≤8周的染色体异常率(58.14%,25/43)高于8~12周(41.86%,18/43),差异有统计学意义(P0.0167)。流产1~5次的染色体异常率与流产0次比较,口服叶酸与未口服叶酸比较,差异无统计学意义(P0.05)。结论:胚胎绒毛染色体异常是引起稽留流产的重要因素,稽留流产的胚胎绒毛染色体异常与年龄、胚胎孕周密切相关,与是否口服叶酸、流产次数(0~5次)无显著关系。
[Abstract]:Objective: to investigate the relationship between chromosomal abnormalities of embryo villi and oral folic acid, age, gestational weeks and times of abortion in missed abortion. Methods: 82 cases of embryo chorionic villi with missed abortion were collected. The chromosomes of embryo villi were detected by a new generation of gene sequencing (NGS) technique. The relationship between oral folic acid, age, gestational weeks, times of abortion and chromosomal abnormalities was analyzed. Results: of the 82 aborted embryos, 46 (56.1010 / 82) were abnormal in number (82.61 / 46), 8 (17.3939 / 8 / 46) in structure, 89.47% (34 / 38) in trisomy, 89.47% (34 / 38) in trisomy, the influence of gestational weeks on age was excluded from 82 cases of embryo chorionic chromosomes, among which 38 cases were abnormal in number (82.61%), 8 cases (17.39% / 46) were abnormal in structure, and 89.47% (34 / 38) in trisomy. A total of 74 cases of embryo villus staining were selected from 25 to 39 year old pregnant women. The chromosomal abnormality rate was 62.16% (46 / 74), and the chromosome abnormality rate was 43.48% / 20 / 46 in 35 and 39 years old, higher than that in 30 ~ 34 years old (23.91 / 11 / 46), 25 ~ 30 years old (32.61 / 15 / 46), the difference was statistically significant (P0.05). The difference was not statistically significant (P0.05). In 82 cases of embryo chorionic chromosomes, the influence of age and other factors on gestational weeks was not significant (P0.05). There were 78 cases of embryo stopping gestational week 812 weeks. The chromosomal abnormality rate was 55.13% (43 / 78). The chromosomal abnormality rate (58.14 / 25 / 43) at gestational age 鈮，
本文编号：2286061
[Abstract]:Objective: to investigate the relationship between chromosomal abnormalities of embryo villi and oral folic acid, age, gestational weeks and times of abortion in missed abortion. Methods: 82 cases of embryo chorionic villi with missed abortion were collected. The chromosomes of embryo villi were detected by a new generation of gene sequencing (NGS) technique. The relationship between oral folic acid, age, gestational weeks, times of abortion and chromosomal abnormalities was analyzed. Results: of the 82 aborted embryos, 46 (56.1010 / 82) were abnormal in number (82.61 / 46), 8 (17.3939 / 8 / 46) in structure, 89.47% (34 / 38) in trisomy, 89.47% (34 / 38) in trisomy, the influence of gestational weeks on age was excluded from 82 cases of embryo chorionic chromosomes, among which 38 cases were abnormal in number (82.61%), 8 cases (17.39% / 46) were abnormal in structure, and 89.47% (34 / 38) in trisomy. A total of 74 cases of embryo villus staining were selected from 25 to 39 year old pregnant women. The chromosomal abnormality rate was 62.16% (46 / 74), and the chromosome abnormality rate was 43.48% / 20 / 46 in 35 and 39 years old, higher than that in 30 ~ 34 years old (23.91 / 11 / 46), 25 ~ 30 years old (32.61 / 15 / 46), the difference was statistically significant (P0.05). The difference was not statistically significant (P0.05). In 82 cases of embryo chorionic chromosomes, the influence of age and other factors on gestational weeks was not significant (P0.05). There were 78 cases of embryo stopping gestational week 812 weeks. The chromosomal abnormality rate was 55.13% (43 / 78). The chromosomal abnormality rate (58.14 / 25 / 43) at gestational age 鈮，
本文编号：2286061
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