囊胚培养患者选择标准的建立及临床应用研究

发布时间：2018-10-21 20:49

【摘要】：目的:旨在建立一套能使更多患者从囊胚培养和移植中受益的选择标准。方法:回顾性分析2011年3月至2012年10月在云南省第一人民医院生殖医学中心实行的两套囊胚培养患者的选择标准。旧标准(844周期):D3选择2个评分最高的胚胎进行移植或冷冻后,若剩余胚胎≥7个,行囊胚培养;新标准(781周期):D3选择2个评分最高的胚胎进行移植或冷冻后,若剩余胚胎≥5个,行囊胚培养。对两组患者IVF的治疗结局进行比较。结果:新标准组患者的获卵数(18.01±7.01个)低于旧标准组(19.42±6.27个),差异有统计学意义(P=0.006);新标准组的患者无囊胚形成率(5.6%)高于旧标准组(2.3%),差异有统计学意义(P=0.001)。新、旧标准两组患者在囊胚形成率、优质囊胚形成率、囊胚复苏率、每周期冻融胚胎移植数、冻融囊胚移植临床妊娠率、囊胚种植率、多胎率和流产率上比较,差异均无统计学意义(P0.05)。结论:降低囊胚培养患者的选择标准可以使更多患者从囊胚培养和移植中受益。
[Abstract]:Objective: to establish a set of selection criteria that can benefit more patients from blastocyst culture and transplantation. Methods: the selection criteria of two sets of blastocyst culture patients were analyzed retrospectively from March 2011 to October 2012 in the Reproductive Medicine Center of the first people's Hospital of Yunnan Province. The old criteria (844 cycles): D3 selected two embryos with the highest score for transfer or freezing, and if the remaining embryos were more than 7, blastocyst culture was performed, and the new standard (781 cycles): D3 selected two highest graded embryos for transfer or freezing. If the remaining embryos were more than 5, blastocyst culture was performed. The outcomes of IVF were compared between the two groups. Results: the number of oocytes in the new standard group (18.01 卤7.01) was lower than that in the old standard group (19.42 卤6.27), the difference was statistically significant (P0. 006), and the blastocyst formation rate in the new standard group (5. 6%) was higher than that in the old standard group (2. 3%) (P 0. 001). The rate of blastocyst formation, the rate of blastocyst resuscitation, the number of frozen and thawed embryos transferred per cycle, the clinical pregnancy rate of frozen and thawed blastocyst transplantation, the rate of blastocyst implantation, the rate of multiple births and the rate of abortion were compared between the two groups. The difference was not statistically significant (P0.05). Conclusion: reducing the selection criteria of blastocyst culture patients can benefit more patients from blastocyst culture and transplantation.
【作者单位】：云南省第一人民医院;
【分类号】：R714.8

【参考文献】