卵巢浆液性囊腺癌中孕激素核受体A、B亚型的表达及临床意义
发布时间：2018-10-24 12:58
【摘要】：目的探讨孕激素核受体A、B亚型(PR-A、PR-B)在卵巢浆液性囊腺癌(ovarian serous cystadenocarcinoma,OSC)发生、发展中的作用。方法采用免疫组化Eli Vision法检测52例OSC、22例卵巢交界性浆液性囊腺瘤(ovarian borderline serous cystadenoma,OBSC)、22例正常输卵管伞端(umbrella of normal fallopian,UNF)中PR-A、PR-B的表达。结果 OSC、OBSC和UNF中的PR-A阳性率分别为94.5%、94.5%、68.38%,三组相比差异有显著性(P0.05);OSC、OBSC和UNF中的PR-B阳性率分别为100%、77.27%、40.38%,三组相比差异有显著性(P0.05);三组中PR-A/PR-B的比值,差异有显著性(P0.05)。PR-A、PR-B表达逐渐下降,Ⅰ+Ⅱ期与Ⅲ+Ⅳ期比较、Ⅰ级与Ⅱ级比较,差异有显著性(P0.05);PR-A/PR-B比值在Ⅰ级与Ⅱ级组相比,差异有显著性(P0.05);PR-B表达在OSC有、无淋巴结转移组间差异有显著性(P0.05)。PR-A、PR-B在OSC组织中表达呈正相关(P0.05)。结论随着OSC恶性变的发生、发展PR-A、PR-B表达逐渐下调,其中PR-B下调更为明显,可能是卵巢组织恶性变的标志;PR-A/PR-B比值的增大可能预示卵巢癌分化越差;PR-B相对高表达有利于抑制OSC的淋巴结转移。
[Abstract]:Objective to investigate the role of progesterone nuclear receptor (PR-A,PR-B) in the pathogenesis and development of ovarian serous cystadenocarcinoma (ovarian serous cystadenocarcinoma,OSC). Methods the expression of PR-A,PR-B in 52 cases of ovarian borderline serous cystadenoma (ovarian borderline serous cystadenoma,OBSC) and 22 cases of normal fallopian tube (umbrella of normal fallopian,UNF) was detected by immunohistochemical Eli Vision method. Results the positive rates of PR-A in OSC,OBSC and UNF were 94.5% and 94.55%, respectively, with significant difference among the three groups (P0.05), and the positive rates of PR-B in OSC,OBSC and UNF were 77.2740.38%, respectively. There was significant difference among the three groups (P0.05), the ratio of PR-A/PR-B in the three groups was decreased gradually (P0.05), the expression of PR-A,PR-B decreased gradually (P0.05). There was significant difference between 鈪，
本文编号：2291482
[Abstract]:Objective to investigate the role of progesterone nuclear receptor (PR-A,PR-B) in the pathogenesis and development of ovarian serous cystadenocarcinoma (ovarian serous cystadenocarcinoma,OSC). Methods the expression of PR-A,PR-B in 52 cases of ovarian borderline serous cystadenoma (ovarian borderline serous cystadenoma,OBSC) and 22 cases of normal fallopian tube (umbrella of normal fallopian,UNF) was detected by immunohistochemical Eli Vision method. Results the positive rates of PR-A in OSC,OBSC and UNF were 94.5% and 94.55%, respectively, with significant difference among the three groups (P0.05), and the positive rates of PR-B in OSC,OBSC and UNF were 77.2740.38%, respectively. There was significant difference among the three groups (P0.05), the ratio of PR-A/PR-B in the three groups was decreased gradually (P0.05), the expression of PR-A,PR-B decreased gradually (P0.05). There was significant difference between 鈪，
本文编号：2291482
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