补肾益气和血法对IVF-ET患者血清和卵泡液性激素水平的影响
发布时间：2018-10-30 12:28
【摘要】：目的观察补肾益气和血法中药对IVF-ET患者血清和卵泡液性激素水平的影响,探讨补肾益气和血法中药对IVF-ET患者生殖内分泌的作用。方法将自2016年4月~2017年1月在湖北省妇幼保健院生殖中心行IVF-ET的不孕妇女随机分配为中药组(51例)和对照组(48例)。对照组采用单纯辅助生殖技术,中药组在对照组方法上加用补肾益气和血法中药治疗。比较两组:(1)基础(月经第3天)和启动日血清FSH、LH、E2、P、T、PRL水平,(2)HCG注射日血清LH、E2、P、T水平,(3)OPU日血清E2、P、T水平,(4)卵泡液中E2、P、T水平,(5)使用Gn的天数和Gn的总量。结果(1)启动日,中药组血清E2水平显著低于对照组,两组比较有显著性差异(P=0.01),而FSH、LH、P、T、RPL无统计学差异(P0.05);(2)HCG注射日,中药组血清E2水平显著高于对照组,两组比较有显著性差异(P0.05),而LH、P、T两组水平相当,无显著性差异(P0.05);(3)OPU日,两组血清E2、P中药组显者高于对照组,均有显著性差异(P0.05),T两组比较无显著性差异(P0.05);(4)卵泡液E2、T两组比较,中药组明显高于对照组,均有显著性差异(均P0.05),两组P比较无显著性差异(P0.05);(5)两组Gn用量和使用天数相比,中药组Gn天数和Gn用量均小于对照组,有统计学差异(P0.01)。结论本研究提示,补肾益气和血法中药介入IVF-ET过程,可能影响血清和卵泡液中激素水平,可能降调启动日血清E2水平,升调HCG日血清E2水平、OPU日血清E2和P水平以及卵泡液E2、T水平,增加卵泡对外源性Gn的敏感性。
[Abstract]:Objective to observe the effect of traditional Chinese medicine of tonifying kidney and supplementing qi and blood on the levels of sex hormones in serum and follicular fluid of patients with IVF-ET, and to explore the effect of traditional Chinese medicine of tonifying kidney and tonifying qi and blood on reproductive endocrine of patients with IVF-ET. Methods infertile women who received IVF-ET from April 2016 to January 2017 were randomly assigned to traditional Chinese medicine group (51 cases) and control group (48 cases). The control group was treated with simple assisted reproductive technique, while the control group was treated with traditional Chinese medicine of tonifying kidney and supplementing qi and blood. The serum FSH,LH,E2,P,T,PRL levels were compared between the two groups: (1) the serum FSH,LH,E2,P,T,PRL level on the 3rd day of menstruation, (2) the serum LH,E2,P,T level on the day of HCG injection, and (3) the serum E _ 2 ~ (2 +) P _ (+) T level on the day of OPU. (4) the level of E _ 2 ~ (2 +) P ~ (+) T in follicular fluid, (5) the days of using Gn and the total amount of Gn. Results (1) on the startup day, the serum E _ 2 level in the traditional Chinese medicine group was significantly lower than that in the control group, and there was a significant difference between the two groups (P0.01), but there was no significant difference in FSH,LH,P,T,RPL between the two groups (P0.05). (2) on the day of HCG injection, the serum E _ 2 level in the Chinese medicine group was significantly higher than that in the control group, and there was a significant difference between the two groups (P0.05), while the level of LH,P,T in the two groups was the same (P0.05). (3) on OPU day, the serum E2P of the two groups was significantly higher than that of the control group (P0.05). There was no significant difference between the two groups (P0.05). (4) compared with the control group, the Chinese medicine group was significantly higher than that of the control group (P0.05), but there was no significant difference between the two groups (P0.05). (5) compared with the two groups, the dosage of Gn and the dosage of Gn in the traditional Chinese medicine group were lower than those in the control group (P0.01). Conclusion this study suggests that the intervention of traditional Chinese medicine of tonifying kidney and tonifying qi and blood in the process of IVF-ET may affect the levels of hormones in serum and follicular fluid, decrease the level of serum E2 on the start day, and adjust the level of serum E2 on the day of ascending HCG. On the day of OPU, the levels of E _ 2 and P in serum and E _ 2 T in follicular fluid increased the sensitivity of follicle to exogenous Gn.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.8
本文编号：2300015
[Abstract]:Objective to observe the effect of traditional Chinese medicine of tonifying kidney and supplementing qi and blood on the levels of sex hormones in serum and follicular fluid of patients with IVF-ET, and to explore the effect of traditional Chinese medicine of tonifying kidney and tonifying qi and blood on reproductive endocrine of patients with IVF-ET. Methods infertile women who received IVF-ET from April 2016 to January 2017 were randomly assigned to traditional Chinese medicine group (51 cases) and control group (48 cases). The control group was treated with simple assisted reproductive technique, while the control group was treated with traditional Chinese medicine of tonifying kidney and supplementing qi and blood. The serum FSH,LH,E2,P,T,PRL levels were compared between the two groups: (1) the serum FSH,LH,E2,P,T,PRL level on the 3rd day of menstruation, (2) the serum LH,E2,P,T level on the day of HCG injection, and (3) the serum E _ 2 ~ (2 +) P _ (+) T level on the day of OPU. (4) the level of E _ 2 ~ (2 +) P ~ (+) T in follicular fluid, (5) the days of using Gn and the total amount of Gn. Results (1) on the startup day, the serum E _ 2 level in the traditional Chinese medicine group was significantly lower than that in the control group, and there was a significant difference between the two groups (P0.01), but there was no significant difference in FSH,LH,P,T,RPL between the two groups (P0.05). (2) on the day of HCG injection, the serum E _ 2 level in the Chinese medicine group was significantly higher than that in the control group, and there was a significant difference between the two groups (P0.05), while the level of LH,P,T in the two groups was the same (P0.05). (3) on OPU day, the serum E2P of the two groups was significantly higher than that of the control group (P0.05). There was no significant difference between the two groups (P0.05). (4) compared with the control group, the Chinese medicine group was significantly higher than that of the control group (P0.05), but there was no significant difference between the two groups (P0.05). (5) compared with the two groups, the dosage of Gn and the dosage of Gn in the traditional Chinese medicine group were lower than those in the control group (P0.01). Conclusion this study suggests that the intervention of traditional Chinese medicine of tonifying kidney and tonifying qi and blood in the process of IVF-ET may affect the levels of hormones in serum and follicular fluid, decrease the level of serum E2 on the start day, and adjust the level of serum E2 on the day of ascending HCG. On the day of OPU, the levels of E _ 2 and P in serum and E _ 2 T in follicular fluid increased the sensitivity of follicle to exogenous Gn.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.8
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