美国最新高危型人乳头状瘤病毒检测用于宫颈癌初筛指南介绍
发布时间：2018-10-30 15:22
【摘要】：继2011年ACS(American Cancer Society,ACS)、ASCCP(American Society of Colposcopy and Cervica I Pathology,ASCCP)、ASCP(American Society of Clinical Pathology,ASCP)对宫颈癌及癌前病变筛查指南公布后,随着几项大型临床研究数据的发表,支持hr HPV检测用于初筛的证据越来越多。特别是在美国本土的一项前瞻性研究"满足高级别HPV诊断需求(Addressing the Need for Advanced HPV Diagnostics,ATHENA)"试验,揭示hr HPV检测用于初筛在单轮筛查中对于CIN2、CIN3的敏感性优于单独细胞学筛查,并明确提出对hr HPV阳性女性分流的策略。本文旨在对美国最新hr HPV检测用于宫颈癌初筛指南的新建议及相关证据进行介绍,同时提出对过渡期指南临床应用时带来的问题包括hr HPV取样的质量控制以及可能存在不同于HPV致癌的其他肿瘤发生途径等临床研究的必要性。
[Abstract]:Following the release of ACS (American Cancer Society,ACS), ASCCP (American Society of Colposcopy and Cervica I Pathology,ASCCP), ASCP (American Society of Clinical Pathology,ASCP guidelines for screening cervical cancer and precancerous lesions in 2011, with the publication of data from several large clinical studies, Evidence supporting hr HPV testing for primary screening is increasing. In particular, a prospective study in the United States, "meeting the High level HPV Diagnostic needs (Addressing the Need for Advanced HPV Diagnostics,ATHENA)" trial, revealed that hr HPV testing was more sensitive to CIN2,CIN3 than single cytological screening in a single round of screening. The strategy of shunt hr HPV positive women was put forward. The purpose of this paper is to introduce the new recommendations and relevant evidence of the latest hr HPV test for cervical cancer screening in the United States. At the same time, the problems arising from clinical application of transitional guidelines include the quality control of hr HPV sampling and the necessity of clinical research on the possible existence of other tumorigenesis pathways different from HPV carcinogenesis.
【作者单位】： 南京医科大学第一临床医学院;南京医科大学第一附属医院妇科;
【分类号】：R737.33
[Abstract]:Following the release of ACS (American Cancer Society,ACS), ASCCP (American Society of Colposcopy and Cervica I Pathology,ASCCP), ASCP (American Society of Clinical Pathology,ASCP guidelines for screening cervical cancer and precancerous lesions in 2011, with the publication of data from several large clinical studies, Evidence supporting hr HPV testing for primary screening is increasing. In particular, a prospective study in the United States, "meeting the High level HPV Diagnostic needs (Addressing the Need for Advanced HPV Diagnostics,ATHENA)" trial, revealed that hr HPV testing was more sensitive to CIN2,CIN3 than single cytological screening in a single round of screening. The strategy of shunt hr HPV positive women was put forward. The purpose of this paper is to introduce the new recommendations and relevant evidence of the latest hr HPV test for cervical cancer screening in the United States. At the same time, the problems arising from clinical application of transitional guidelines include the quality control of hr HPV sampling and the necessity of clinical research on the possible existence of other tumorigenesis pathways different from HPV carcinogenesis.
【作者单位】： 南京医科大学第一临床医学院;南京医科大学第一附属医院妇科;
【分类号】：R737.33
【共引文献】
相关期刊论文 前10条
1 王慧峰;;宫颈癌认知及筛查的临床意义[J];甘肃医药;2013年10期
2 陈锐;赵健;廖秦平;;复方沙棘籽油栓治疗宫颈HPV感染的临床观察[J];中国妇产科临床杂志;2013年06期
3 孙选;韩韬;林峰;孔守芳;李旭日;刘爱红;;宫颈病变患者配偶人乳头瘤病毒感染的相关性临床分析[J];中国妇产科临床杂志;2014年01期
4 许晓跃;于农;陈建魁;张伟;;北京丰台区女性人乳头瘤病毒感染及分型[J];中国感染控制杂志;2013年06期
5 王健;曹昭;易珍;;2324例门诊患者人乳头瘤病毒感染状况及亚型分析[J];广西医学;2014年01期
6 尤志学;;HPV16、18高危亚型的风险分层管理作用——更加有效的宫颈癌筛查举措[J];国际检验医学杂志;2014年03期
7 黄成琳;张淑兰;;人乳头瘤病毒衣壳蛋白与宫颈病变[J];国际妇产科学杂志;2014年02期
8 莫小亮;罗殿中;党裔武;王莉;;不同程度宫颈病变单一、多重高危型HPV感染状态下E6/E7 mRNA的表达[J];重庆医学;2014年18期
9 魏葆s，
本文编号：2300382
本文链接：https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2300382.html
最近更新
教材专著
