血清胱抑素C在妊娠期高血压疾病中的临床价值

发布时间：2018-11-01 15:22

【摘要】：目的探讨血清胱抑素C(Cystatin C,CC)的检测在妊娠期高血压疾病中的临床价值。方法收集北京妇产医院2012年2月至2012年8月妊娠高血压患者22例、轻度子痫前期患者20例、重度子痫前期患者25例,并选择同期孕周相匹配的健康孕妇30例作为对照组。比较妊娠期高血压疾病组间及与健康孕妇组CC、SCr、BUN和UA的差异,比较不良妊娠结局组与无不良妊娠结局组CC、SCr、BUN和UA的差异。结果妊娠期高血压疾病及各亚组患者CC和UA均较健康孕妇明显增高(P0.05),且重度子痫前期患者升高更明显(P0.05)。与正常妊娠组比较,妊娠高血压疾病组CC和UA分别上升了97.4%和47.4%。妊娠高血压疾病各亚组患者中CC和UA超过正常值患者例数重度子痫前期轻度子痫妊娠期高血压。不良妊娠结局组患者的血清CC、SCr和UA均高于无不良妊娠结局组(P0.05)。结论 CC是评价妊娠期高血压疾病患者早期肾脏损害的一项敏感和可靠的指标,其可能作为不良妊娠结局的预测指标。
[Abstract]:Objective to investigate the clinical value of serum cystatin C (Cystatin CC in hypertensive disorder complicating pregnancy. Methods from February 2012 to August 2012, 22 cases of pregnancy hypertension, 20 cases of mild preeclampsia and 25 cases of severe preeclampsia were collected from Beijing Obstetrics and Gynecology Hospital, and 30 healthy pregnant women were selected as control group. To compare the difference of CC,SCr,BUN and UA between hypertensive disorder complicating pregnancy group and healthy pregnant women, and to compare the difference of CC,SCr,BUN and UA between poor pregnancy outcome group and non-adverse pregnancy outcome group. Results the CC and UA of hypertensive disorder complicating pregnancy and each subgroup were significantly higher than those of healthy pregnant women (P0.05), and that of patients with severe preeclampsia were more significant (P0.05). Compared with normal pregnancy group, CC and UA increased by 97.4% and 47.4%, respectively. The number of patients with severe preeclampsia, mild eclampsia, pregnancy hypertension complicating hypertension with CC and UA exceeded the normal value in each subgroup of pregnancy-induced hypertension. The serum CC,SCr and UA of patients with adverse pregnancy outcomes were higher than those without adverse pregnancy outcomes (P0.05). Conclusion CC is a sensitive and reliable index for evaluating early renal damage in hypertensive disorder complicating pregnancy, and it may be used as a predictor of adverse pregnancy outcome.
【作者单位】：首都医科大学附属北京妇产医院;
【分类号】：R714.246

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