染色体多态性不影响体外受精胚胎移植技术的生殖结局

发布时间：2018-11-02 08:58

【摘要】：目的探讨染色体多态性对体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)助孕患者临床妊娠结局的影响。方法回顾性分析2015年3月—2016年6月在第二军医大学长海医院生殖医学中心首次进行IVF/ICSI-ET周期不孕不育夫妻的临床资料。根据夫妻一方或双方染色体是否存在多态性分为2组:染色体多态性组(夫妻一方或双方存在染色体多态性)和染色体正常组(夫妻双方染色体均正常)。比较分析两组夫妻在IVF/ICSI-ET治疗后的胚胎种植率、临床妊娠率、早期流产率和每移植周期活产率。结果共纳入1 108对行IVF/ICSI-ET助孕的不孕不育夫妻,其中染色体多态性组69对,染色体正常组1 039对。染色体正常组和染色体多态性组的胚胎种植率(34.91%vs 34.62%,P0.05)、临床妊娠率(49.09%vs 50.72%,P0.05)、早期流产率(11.37%vs 8.57%,P0.05)、每移植周期活产率(41.67%vs 43.47%,P0.05)差异均无统计学意义。结论染色体多态性不影响IVF/ICSI-ET助孕患者的临床结局。
[Abstract]:Objective to investigate the effect of chromosome polymorphism on pregnancy outcome in IVF / intracytoplasmic sperm microinjection-embryo transfer (IVF/ICSI-ET)-assisted pregnancy. Methods the clinical data of infertile couples with IVF/ICSI-ET cycle were retrospectively analyzed from March 2015 to June 2016 at the Center of Reproductive Medicine, Changhai Hospital, second military Medical University. According to the polymorphism of one or both chromosomes of husband and wife, they were divided into two groups: the group of chromosome polymorphisms (one or both of them) and the group of normal chromosomes (the chromosomes of both husband and wife were normal). The embryo implantation rate, clinical pregnancy rate, early abortion rate and live delivery rate per transplant cycle were compared between the two groups after IVF/ICSI-ET treatment. Results A total of 1 108 infertile couples with IVF/ICSI-ET assisted pregnancy were included, including 69 pairs of chromosome polymorphisms and 1 039 pairs of normal chromosomes. The embryo implantation rate (34.91%vs 34.62), clinical pregnancy rate (49.09%vs 50.72%), early abortion rate (11.37%vs 8.57%), embryo implantation rate (34.91%vs 34.62), early abortion rate (11.37%vs 8.57%) in normal chromosome group and chromosome polymorphic group were significantly higher than those in control group. There was no significant difference in live birth rate (41.67%vs 43.47). Conclusion chromosome polymorphism does not affect the clinical outcome of IVF/ICSI-ET assisted pregnancy patients.
【作者单位】：第二军医大学长海医院生殖医学中心;上海市计划生育科学研究所国家人口和计划生育委员会计划生育药具重点实验室;中国科学院遗传与发育生物学研究所;
【分类号】：R714.8

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