CISD2在早期宫颈腺癌中的表达和临床意义

发布时间：2018-11-02 11:40

【摘要】：【目的】:探讨CISD2在早期宫颈腺癌组织中的表达及其与临床特征的关系。【方法】采用免疫组织化学染色法分析CISD2在56例FIGO分期为IB-IIA期的早期宫颈腺癌组织中的表达,并以3例正常宫颈组织作为阴性对照。运用统计学分析CISD2表达水平与早期宫颈腺癌的临床病理特点与预后的关系。【结果】CISD2在FIGO分期为IB-IIA期的早期宫颈腺癌患者组织中44.6%为高表达,55.4%为低表达,在正常宫颈组织中不表达。CISD2的表达水平与早期宫颈腺癌患者深肌层浸润(P=0.023),淋巴结转移(P=0.003)和卵巢转移(P=0.014)有明显相关。高表达CISD2的早期宫颈腺癌患者5年生存率明显低于CISD2低表达患者(P=0.002)。多因素分析提示CISD2的表达水平是早期宫颈腺癌患者总体生存期的独立预测指标(P=0.027)。【结论】在早期宫颈腺癌患者中CISD2的表达与临床特征和预后有关,它可能是一种新的预测早期宫颈腺癌患者预后的分子标志物。
[Abstract]:[objective]: to investigate the expression of CISD2 in early cervical adenocarcinoma and its relationship with clinical features. [methods] Immunohistochemical staining was used to analyze the expression of CISD2 in 56 cases of early cervical adenocarcinoma with IB-IIA stage by FIGO. Three normal cervical tissues were used as negative control. The relationship between the expression of CISD2 and the clinicopathological features and prognosis of early cervical adenocarcinoma was analyzed statistically. [results] the expression of CISD2 was high in 44.6% and low in 55.4% of early cervical adenocarcinoma patients with IB-IIA stage by FIGO. There was no expression of CISD2 in normal cervical tissues. The expression level of CISD2 was significantly correlated with deep myometrial infiltration (P0. 023), lymph node metastasis (P0. 003) and ovarian metastasis (P0. 014) in patients with early cervical adenocarcinoma. The 5-year survival rate of early cervical adenocarcinoma patients with high expression of CISD2 was significantly lower than that of patients with low expression of CISD2 (P0. 002). Multivariate analysis showed that the expression of CISD2 was an independent predictor of the overall survival time of early cervical adenocarcinoma (P0. 027). [conclusion] the expression of CISD2 in early cervical adenocarcinoma is related to clinical features and prognosis. It may be a new molecular marker for predicting the prognosis of early cervical adenocarcinoma.
【作者单位】：中山大学附属第一医院妇产科;
【基金】：广东省自然科学基金(S2013010015552)
【分类号】：R737.33

【参考文献】