术前血浆D-二聚体水平与浆液性卵巢癌一线化疗疗效及预后的相关性评价

发布时间：2018-11-02 17:23

【摘要】：目的:探讨术前血浆D-二聚体水平与浆液性卵巢癌一线化疗疗效及预后的相关性。方法:回顾性分析天津医科大学肿瘤医院2008年1月至2010年5月143例浆液性卵巢癌患者的术前血浆D-二聚体水平,并依据血浆D-二聚体正常水平分为血浆D-二聚体水平(≤0.3 mg/L)正常组(100例)和血浆D-二聚体水平(0.3 mg/L)升高组(43例),比较血浆D-二聚体不同水平与临床病理因素、化疗疗效及预后的相关性。结果:血浆D-二聚体水平与FIGO分期、残余病灶大小、恶性腹水、术前CA125水平及新辅助化疗密切相关。化疗后血浆D-二聚体水平升高组的完全缓解率34.88%(15/43)明显低于血浆D-二聚体正常组73.00%(73/100),两者比较差异具有统计学意义(P0.001)。血浆D-二聚体水平升高组的无进展生存率与总生存率明显低于血浆D-二聚体正常组(25.58%vs.50.00%与32.56%vs.65.00%),两者比较差异具有统计学意义(P0.05)。Cox多因素分析显示血浆D-二聚体水平是患者预后的独立预测因素。结论:术前血浆D-二聚体水平可作为有效预测浆液性卵巢癌一线化疗疗效及预后的生物学指标。
[Abstract]:Objective: to investigate the correlation between plasma D-dimer level and first-line chemotherapeutic effect and prognosis of serous ovarian cancer. Methods: the plasma levels of D-dimer in 143 patients with serous ovarian cancer from January 2008 to May 2010 in Tianjin Medical University Oncology Hospital were retrospectively analyzed. According to the normal level of plasma D-dimer, the patients were divided into two groups: normal group (100 cases) with plasma D-dimer level (鈮，

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