孕酮对孕早期不良妊娠史妇女妊娠结局的影响以及预测价值

发布时间：2018-11-02 17:52

【摘要】：目的:观察补充孕酮对孕早期不良妊娠史妇女妊娠结局的影响,并应用受试者工作特征(ROC)曲线评价孕酮水平对其妊娠结局的预测价值。方法:选取2014年1月至2015年4月于我院门诊就诊的既往有早期不良妊娠史的早孕患者56例为研究组(据治疗情况分为治疗组40例和未治疗组16例),同期常规体检的正常早孕妇女183例为对照组,对比分析治疗组与未治疗组患者的妊娠结局,并应用ROC曲线对孕酮水平进行分析评价。结果:研究组与对照组孕酮水平比较差异无统计学意义(P0.05);治疗组与未治疗组妊娠结局比较差异无显著性(P0.05);血清孕酮水平判断早期不良妊娠史妇女妊娠结局的ROC曲线下面积为0.692,最佳临界值为19.74 ng/m L,此时灵敏度和特异度分别为0.588和0.762。结论:补充孕酮对早期不良妊娠史妇女的妊娠结局无显著影响。首次测得孕酮水平可用于判断不良妊娠史妇女的妊娠结局。
[Abstract]:Aim: to observe the effect of progesterone supplementation on pregnancy outcome in women with adverse pregnancy history in early pregnancy and to evaluate the predictive value of progesterone level on pregnancy outcome by using (ROC) curve. Methods: from January 2014 to April 2015, 56 cases of early pregnancy with history of early adverse pregnancy were selected as study group (40 cases in treatment group and 16 cases in untreated group). There were 183 normal early pregnant women in the same period as control group. The pregnancy outcome of the treatment group and the untreated group was compared and the progesterone level was evaluated by ROC curve. Results: there was no significant difference in progesterone levels between the study group and the control group (P0.05), while there was no significant difference in the pregnancy outcome between the treatment group and the untreated group (P0.05). The area under the ROC curve of serum progesterone level was 0.692 and the best critical value was 19.74 ng/m / L, the sensitivity and specificity were 0.588 and 0.762respectively. Conclusion: progesterone supplementation has no significant effect on pregnancy outcome of women with early adverse pregnancy history. Progesterone levels were measured for the first time to determine the outcome of pregnancy in women with poor pregnancy history.
【作者单位】：陕西中医药大学第二临床医学院;西电集团医院;
【分类号】：R714.2

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