控制性超排卵中hCG日孕酮水平与妊娠结局的关系
发布时间：2018-11-06 19:55
【摘要】：目的探讨在控制性超排卵(COH)中体外受精-胚胎移植(IVF-ET)不同卵巢反应患者hCG注射日孕酮水平对妊娠结局的影响。方法回顾性分析行IVF-ET的1077例患者的资料,根据获卵数将卵巢反应分为高反应组、正常反应组和低反应组。均采用黄体期长方案控制性促排卵。化学发光法检测hCG日孕酮(P)水平。根据P水平分组:3.18 nmol/L、3.18~3.98 nmol/L、3.99~4.77 nmol/L、4.78~5.57 nmol/L、5.58~6.36 nmol/L、6.36 nmol/L。分别比较不同反应组新鲜周期的妊娠率、获卵数、优胚数及妊娠结局。结果 1高反应组及正常反应组6.36 nmol/L患者临床妊娠率最低(18.75%,3/16;12.50%,2/16),低反应组P4.77 nmol/L患者临床妊娠率低(9.09%,1/11);2高反应组及正常反应组P≤6.36 nmol/L组临床妊娠率(44.88%,114/238;42.19%,278/659)较6.36 nmol/L组高(18.75%,3/16;12.5%,2/16;P0.05);3低反应组P≤4.77 nmol/L组临床妊娠率较4.77 nmol/L组高(41.35%,55/133;6.67%,3/16;P0.05)。各组获卵数和优胚数比较,差异均无统计学意义(P0.05)。结论 hCG日血清P水平明显升高可影响IVF-ET的妊娠率。卵巢不同反应者其P升高影响妊娠率的切点值不同。
[Abstract]:Objective to investigate the effect of progesterone level on pregnancy outcome in patients with different ovarian reactions during in vitro fertilization and embryo transfer (IVF-ET) in controlled hyperovulation (COH). Methods the data of 1077 patients with IVF-ET were analyzed retrospectively. The ovarian response was divided into high response group, normal response group and low response group according to the number of oocytes obtained. Ovulation was controlled by long luteal phase regimen. The level of progesterone (P) in hCG was detected by chemiluminescence assay. Grouped according to P level: 3.18 nmol/L,3.18~3.98 nmol/L,3.99~4.77 nmol/L,4.78~5.57 nmol/L,5.58~6.36 nmol/L,6.36 nmol/L. The pregnancy rate, the number of eggs, the number of embryos and the outcome of pregnancy were compared in different response groups. Results (1) the clinical pregnancy rate of 6.36 nmol/L patients in the high response group and the normal reaction group was the lowest (18.7575 / 3 / 16 12.50 / 2 / 16), while in the low reaction group P4.77 nmol/L was low (9.09 / 11). 2 the clinical pregnancy rate (P 鈮，
本文编号：2315305
[Abstract]:Objective to investigate the effect of progesterone level on pregnancy outcome in patients with different ovarian reactions during in vitro fertilization and embryo transfer (IVF-ET) in controlled hyperovulation (COH). Methods the data of 1077 patients with IVF-ET were analyzed retrospectively. The ovarian response was divided into high response group, normal response group and low response group according to the number of oocytes obtained. Ovulation was controlled by long luteal phase regimen. The level of progesterone (P) in hCG was detected by chemiluminescence assay. Grouped according to P level: 3.18 nmol/L,3.18~3.98 nmol/L,3.99~4.77 nmol/L,4.78~5.57 nmol/L,5.58~6.36 nmol/L,6.36 nmol/L. The pregnancy rate, the number of eggs, the number of embryos and the outcome of pregnancy were compared in different response groups. Results (1) the clinical pregnancy rate of 6.36 nmol/L patients in the high response group and the normal reaction group was the lowest (18.7575 / 3 / 16 12.50 / 2 / 16), while in the low reaction group P4.77 nmol/L was low (9.09 / 11). 2 the clinical pregnancy rate (P 鈮，
本文编号：2315305
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