单侧输卵管切除术对异位妊娠患者卵巢储备和IVF结局的影响
发布时间：2018-11-07 17:45
【摘要】：目的探讨异位妊娠患者行输卵管切除后对于卵巢储备、卵巢反应性和体外受精(IVF)结局的影响。方法选取行单侧输卵管切除术后行体外受精-胚胎移植(IVF-ET)助孕的患者为手术组(n=85),同期行IVF助孕的未行输卵管手术的患者为对照组(n=68)。分析指标包括卵巢储备[抗苗勒氏管激素(AMH)、窦卵泡数(AFC)、血清基础性激素水平(FSH、E2、FSH/E2比值)]、卵巢反应性以及IVF结局(Gn总量、Gn天数、HCG日子宫内膜厚度、E2峰值水平、获卵数、优胚数及临床妊娠率)。结果与对照组相比,手术组AMH水平下降(P0.05),AFC下降(P0.05),FSH、E2、FSH/E2比值差异均无统计学意义(均P0.05)。手术组85名患者,进一步对手术侧与非手术侧卵巢功能进行比较,结果表明,手术侧卵巢AFC下降(P0.05),获卵数和卵巢体积无统计学差异(均P0.05)。手术组与对照组相比,Gn总量、Gn天数、HCG日子宫内膜厚度、E2峰值水平、获卵数、优胚数及临床妊娠率等差异均无统计学意义(均P0.05)。结论单侧输卵管切除术会导致卵巢储备下降,但对卵巢反应性和IVF结局无影响。
[Abstract]:Objective to investigate the effects of oviductal resection on ovarian reserve, ovarian reactivity and (IVF) outcome of in vitro fertilization in patients with ectopic pregnancy. Methods the patients who underwent in vitro fertilization and embryo transfer (IVF-ET) after unilateral salpingotomy were selected as the operative group (nm85), and those who were not undergoing the tubal operation with IVF (NN68) were selected as the control group. The indexes included ovarian reserve [(AMH), antral follicle number], ovarian reactivity and IVF outcome (Gn total, Gn days), serum basic sex hormone level (FSH,E2,FSH/E2 ratio) in (AFC),. On the day of HCG, the thickness of endometrium, the peak level of E _ 2, the number of eggs obtained, the number of superior embryos and the clinical pregnancy rate. Results compared with the control group, the level of AMH in the operation group decreased (P0.05), AFC decreased (P0.05), the ratio of FSH,E2,FSH/E2 was not significantly different (P0.05). The ovarian function of the operative side and the non-operative side were further compared in the operation group (85 patients). The results showed that the AFC of the operative side decreased (P0.05), the number of oocytes obtained and the ovarian volume had no statistical difference (P0.05). Compared with the control group, there were no significant differences in total Gn, days of Gn, thickness of endometrium, peak level of E2, number of eggs acquired, number of excellent embryos and clinical pregnancy rate in the operation group (P0.05). Conclusion unilateral salpingotomy can decrease ovarian reserve, but has no effect on ovarian reactivity and IVF outcome.
【作者单位】： 武汉大学人民医院生殖医学中心;
【基金】：湖北省自然科学基金资助项目(No.2016CFB352) 湖北省卫生计生委面上项目(No.WJ2017M011)
【分类号】：R714.8
，
本文编号：2317102
[Abstract]:Objective to investigate the effects of oviductal resection on ovarian reserve, ovarian reactivity and (IVF) outcome of in vitro fertilization in patients with ectopic pregnancy. Methods the patients who underwent in vitro fertilization and embryo transfer (IVF-ET) after unilateral salpingotomy were selected as the operative group (nm85), and those who were not undergoing the tubal operation with IVF (NN68) were selected as the control group. The indexes included ovarian reserve [(AMH), antral follicle number], ovarian reactivity and IVF outcome (Gn total, Gn days), serum basic sex hormone level (FSH,E2,FSH/E2 ratio) in (AFC),. On the day of HCG, the thickness of endometrium, the peak level of E _ 2, the number of eggs obtained, the number of superior embryos and the clinical pregnancy rate. Results compared with the control group, the level of AMH in the operation group decreased (P0.05), AFC decreased (P0.05), the ratio of FSH,E2,FSH/E2 was not significantly different (P0.05). The ovarian function of the operative side and the non-operative side were further compared in the operation group (85 patients). The results showed that the AFC of the operative side decreased (P0.05), the number of oocytes obtained and the ovarian volume had no statistical difference (P0.05). Compared with the control group, there were no significant differences in total Gn, days of Gn, thickness of endometrium, peak level of E2, number of eggs acquired, number of excellent embryos and clinical pregnancy rate in the operation group (P0.05). Conclusion unilateral salpingotomy can decrease ovarian reserve, but has no effect on ovarian reactivity and IVF outcome.
【作者单位】： 武汉大学人民医院生殖医学中心;
【基金】：湖北省自然科学基金资助项目(No.2016CFB352) 湖北省卫生计生委面上项目(No.WJ2017M011)
【分类号】：R714.8
，
本文编号：2317102
本文链接：https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2317102.html
最近更新
教材专著
