D-二聚体及子宫动脉血流在妊娠期高血压疾病中的意义

发布时间：2018-11-07 19:10

【摘要】：目的探讨D-二聚体及子宫动脉血流在妊娠期高血压疾病中的意义。方法采用回顾性研究调查检测120例正常妊娠、34例妊娠期高血压、52例轻度子前期、43例重度子前期孕妇外周血D-二聚体及双侧子宫动脉血流。结果 D-二聚体水平随孕周上升而增高,孕10~14周及孕30~34周外周血D-二聚体含量在正常组(0.11±0.03、0.35±0.79)mg/L明显低于妊娠期高血压组(0.16±0.14、0.74±1.31)mg/L、轻度子前期组(0.35±0.28、2.13±2.27)mg/L、重度子前期组(0.56±0.42、2.98±2.96)mg/L(P0.01)。妊娠期高血压组孕10~14周,30~34周外周血D-二聚体含量明显低于轻度子前期组及重度子前期组(P0.01);轻度子前期组明显低于重度子前期组(P0.01)。子宫动脉血流S/D比值正常组(2.13±0.41)明显低于妊娠期高血压组(2.33±0.21)、轻度子前期组(2.35±0.28)、重度子前期组(2.53±0.48)(P0.01);妊娠期高血压组明显低于轻度子前期组及重度子前期组(P0.01)。轻度子前期组明显低于重度子前期组(P0.01);妊娠期高血压组的D-二聚体含量与子宫动脉S/D值成正比(R=-0.67),轻度子前期组的D-二聚体含量及重度子前期组的D-二聚体含量与子宫动脉S/D值成反比(R=0.75、0.81)。结论监测孕妇外周血D-二聚体指标及子宫动脉血流,对妊娠期高血压疾病特别是重度子前期的早发现、早诊断、早治疗有一定的临床指导意义。
[Abstract]:Objective to investigate the significance of D-dimer and uterine artery blood flow in hypertensive disorder complicating pregnancy. Methods A retrospective study was carried out in 120 cases of normal pregnancy, 34 cases of pregnancy-induced hypertension, 52 cases of mild preantral pregnancy and 43 cases of severe preantral pregnancy. Results the level of D-dimer increased with the increase of gestational week. The levels of D-dimer in peripheral blood of normal group (0.11 卤0.03 卤0.35 卤0.79) mg/L were significantly lower than those of hypertensive complicating pregnancy group (0.16 卤0.14 卤0.74 卤1.31) mg/L,. The mild preantral group (0.35 卤0.28) 2.13 卤2.27 mg/L, severe preantral group (0.56 卤0.42) 2.98 卤2.96 mg/L (P0.01). The level of D-dimer in peripheral blood of hypertensive complicating pregnancy group was significantly lower than that of mild preantral group and severe preantral group (P0.01), and that of mild preantral group was significantly lower than that of severe preantral group (P0.01). The S / D ratio of uterine artery in normal group (2.13 卤0.41) was significantly lower than that in hypertensive complicating pregnancy group (2.33 卤0.21), mild preantral group (2.35 卤0.28) and severe preantral group (2.53 卤0.48) (P0.01). The gestational hypertension group was significantly lower than that of mild preantral group and severe preantral group (P0.01). The mild preantral group was significantly lower than the severe preantral group (P0.01). The content of D-dimer in hypertensive complicating pregnancy group was directly proportional to the S / D value of uterine artery (RP- 0.67). The D-dimer content in the mild preantral group and the severe preantral group was inversely proportional to the S / D value of the uterine artery (R _ (0.75) ~ (0.81). Conclusion the monitoring of peripheral blood D-dimer and uterine artery blood flow in pregnant women is of clinical significance in early detection, early diagnosis and early treatment of hypertensive disorders complicating pregnancy, especially in severe preeclampsia.
【作者单位】：复旦大学附属妇产科医院产科;
【分类号】：R714.246

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