不同剂量复方甲硝唑栓治疗老年性阴道炎的疗效

发布时间：2018-11-09 09:15

【摘要】：目的探究不同剂量复方甲硝唑栓治疗老年性阴道炎的疗效。方法选取海南省儋州农垦那大医院收治的300例老年性阴道炎患者,按随机数字表法分为低剂量组、中剂量组、高剂量组各100例。不同剂量组患者采用不同剂量的复方甲硝唑栓治疗14 d。治疗前后检测不同剂量组患者相关治疗指标水平,观察治疗后各组患者的临床疗效。结果低剂量组、中剂量组、高剂量组老年性阴道炎患者的治愈率分别是22%、37%、52%,总有效率分别达到77%、90%、98%,组间比较差异显著(P0.05);治疗后患者血清雌二醇(E2)、白细胞介素(IL)-1β、p H水平显著低于治疗前,且低剂量组中剂量组高剂量组(P0.05);经过不同剂量复方甲硝唑栓治疗后血清促卵泡生成素(FSH)、免疫球蛋白(s Ig)A水平显著高于治疗前,且低剂量组中剂量组高剂量组(均P0.05)。结论患者的临床疗效随复方甲硝唑栓剂量的提高而提高,同时复方甲硝唑栓剂量能够有效改善患者相关临床指标。
[Abstract]:Objective to explore the effect of compound metronidazole suppository in the treatment of senile vaginitis. Methods 300 patients with senile vaginitis were randomly divided into three groups: low dose group, middle dose group and high dose group. Patients in different dose groups were treated with compound metronidazole suppository for 14 days. Before and after treatment, the relative treatment indexes of patients with different doses were measured, and the clinical efficacy of each group was observed. Results the cure rate of senile vaginitis in low dose group, middle dose group and high dose group was 22 / 3737 / 52.The total effective rate was 77 / 90/ 98, respectively, and the difference between the two groups was significant (P0.05). The levels of serum estradiol (E2) and interleukin (IL) 1 尾, p H in patients after treatment were significantly lower than those before treatment, and the levels of serum estradiol (E 2) and interleukin 1 尾, p H (, p H) were significantly lower in low dose group than in high dose group (P0.05). After different doses of metronidazole suppository, the level of serum (FSH), immunoglobulin (s Ig) A was significantly higher than that before treatment, and the low dose group was high dose group (P0.05). Conclusion the clinical efficacy of patients with metronidazole suppository is improved with the increase of the dosage of compound metronidazole suppository, and the dosage of compound metronidazole suppository can effectively improve the clinical indexes of patients with metronidazole suppository.
【作者单位】：海南现代妇女儿童医院妇产科;海南省农垦那大医院妇产科;
【基金】：海南省卫生厅科学研究课题(琼卫2012-69)
【分类号】：R711.31

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