克罗米芬加HMG方案在POR中的应用

发布时间：2018-11-09 15:37

【摘要】：目的探讨克罗米芬加HMG方案(CC+HMG)在卵巢低反应(poor ovarian response,POR)患者IVF/ICSI-ET周期中应用优势。方法回顾性分析IVF/ICSI—ET治疗的716个卵巢低反应周期的临床资料,按促排卵方案分为四组:CC+HMG组、长方案组、短方案组、拮抗剂组。分别统计并比较各组患者的一般情况、治疗结局及总医疗费用的差异。结果 1 CC+HMG组Gn使用量最少,与其余三组比较差异有统计学意义(P0.05);2 CC+HMG组方案获卵数较其他方案少,周期取消率高,差异有统计学意义(P0.05);3 CC+HMG组及长方案组较其他两组的周期累积胚胎种植率高,差异有统计学意义(P0.05);4 CC+HMG组所需的医疗费用最低,短方案组和拮抗剂组费用接近居中,长方案最高,三者之间差异有统计学意义(P0.05)。结论对于POR患者CC+HMG方案周期费用低,累计种植率高,而累积妊娠率和累积活产率不低于其他方案的优势,是POR患者经济实用的选择。
[Abstract]:Objective to investigate the advantages of clomiphene plus HMG regimen (CC HMG) in the IVF/ICSI-ET cycle of patients with ovarian hyporeactive (poor ovarian response,POR. Methods the clinical data of 716 ovarian hyporesponse cycles treated with IVF/ICSI-ET were retrospectively analyzed. According to the ovulation promotion regimen, the patients were divided into four groups: CC HMG group, long regimen group, short regimen group and antagonist group. The difference of general condition, treatment outcome and total medical cost were analyzed and compared. Results (1) the usage of Gn in CC HMG group was the least, compared with the other three groups, the difference was statistically significant (P0.05), while in CC HMG group, the number of eggs was less and the rate of cycle cancellation was higher (P0.05). 3The rate of cumulative embryo implantation in CC HMG group and long-plan group was higher than that in other two groups (P0.05). (4) the medical cost of CC HMG group was the lowest, the cost of short regimen group and antagonist group was close to the middle, the long scheme was the highest, and the difference among the three groups was statistically significant (P0.05). Conclusion for the patients with POR, the cost of CC HMG regimen is low, the cumulative implantation rate is high, and the cumulative pregnancy rate and cumulative live birth rate are not lower than the advantages of other schemes. It is an economical and practical choice for POR patients.
【作者单位】：北京大学人民医院生殖中心;北京大学首钢医院妇产科;
【基金】：国家卫生和计划生育委员会公益性行业科研专项(2115000011)
【分类号】：R714.8

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