反复植入失败患者移植日子宫内膜蠕动波的研究
发布时间：2018-11-10 11:26
【摘要】：目的：研究反复植入失败患者移植日的子宫内膜蠕动波的情况,探讨反复植入失败患者是否存在子宫内膜蠕动波异常。 方法：本研究采用的是前瞻性巢式病例对照研究方式。经ART治疗的不孕女性的知情同意后,在移植日使用经阴道B超采集其子宫内膜蠕动波的资料并于4倍于正常速度下两名分析人员独立分析频率及类型。追踪其妊娠结局后予以分组,妊娠结局阳性的女性根据其治疗方案分别纳入对应的冻胚周期-妊娠组及鲜胚周期-妊娠组,纳入组的病例数分别为50例和17例；反复植入失败的女性相对应的纳入冻胚周期-RIF组及鲜胚周期-RIF组,获得的病例数分别为32例和11例。比较分析RIF组与妊娠组的子宫内膜蠕动波的频率及类型。 结果： 1.对于子宫内膜蠕动波的频率,鲜胚周期合并冻胚周期的总周期中,RIF组明显高于妊娠组,差异有显著性(2.28±0.58vs.1.81±0.64P0.01)；鲜胚周期-RIF组较鲜胚周期-妊娠组稍高,差异无显著性(1.93±0.36vs.1.64±0.67,P=0.2)；冻胚周期-RIF组明显高于冻胚周期-妊娠组,差异有显著性(2.40±0.59vs.1.88±0.62,P0.01)。 2.子宫内膜蠕动波频率在RIF组中与移植周期数成正相关(r=0.34,P=0.028),在妊娠组中与移植周期数无明显相关关系(r=0.034,P=0.78)。 3.对于不同类型的子宫内膜蠕动波的出现率,无论是鲜胚周期还是冻胚周期中,RIF组与妊娠组差异均无显著性(P0.05)。 4.对于不同类型的子宫内膜蠕动波的构成比,无论是鲜胚周期还是冻胚周期中,RIF组与妊娠组差异均无显著性(P0.05)。 结论： 1.子宫内膜蠕动波频率增高可能是影响反复植入失败患者胚胎着床的原因之一。 2.反复植入失败患者子宫内膜蠕动波频率与移植周期数成正相关。
[Abstract]:Aim: to study the endometrial peristalsis in patients with failed implantation on the day of transplantation, and to investigate whether there is abnormal endometrial peristalsis in patients with repeated failed implantation. Methods: a prospective nested case-control study was conducted. After informed consent of infertile women treated with ART, the data of endometrial peristalsis were collected by transvaginal ultrasound on the day of transplantation, and the frequency and type of endometrial peristalsis were independently analyzed by two analysts at 4 times the normal speed. The women with positive pregnancy outcome were included in the corresponding frozen embryo cycle pregnancy group and the fresh embryo cycle pregnancy group according to their treatment plan. The number of cases in the group were 50 and 17 respectively. The number of women who failed repeatedly in the frozen embryo cycle-RIF group and the fresh embryo cycle-RIF group were 32 and 11, respectively. The frequency and type of endometrial peristalsis in RIF group and pregnancy group were compared. Results: 1. For the frequency of endometrial peristalsis, the frequency of peristaltic wave in RIF group was significantly higher than that in pregnancy group (2.28 卤0.58vs.1.81 卤0.64P0.01). The fresh embryo cycle-RIF group was slightly higher than that of fresh embryo cycle-pregnancy group (1.93 卤0.36vs.1.64 卤0.67P0. 2). The frozen embryo cycle RIF group was significantly higher than that of frozen embryo cycle pregnancy group (2.40 卤0.59vs.1.88 卤0.62p0.01). 2. The frequency of endometrial peristalsis was positively correlated with the number of transplant cycles in RIF group (r = 0.34, P 0.028), but not with the number of transplant cycles in pregnancy group (r = 0.034, P = 0.78). 3. For different types of endometrial peristaltic waves, there was no significant difference between RIF group and pregnancy group in both fresh and frozen embryo cycles (P0.05). 4. For different types of endometrial peristaltic waves, there was no significant difference between RIF group and pregnancy group in both fresh and frozen embryo cycles (P0.05). Conclusion: 1. The increased frequency of endometrial peristalsis may be one of the reasons that affect the implantation of embryos in patients with repeated implantation failure. 2. The frequency of endometrial peristalsis was positively correlated with the number of transplant cycles.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.8
本文编号：2322345
[Abstract]:Aim: to study the endometrial peristalsis in patients with failed implantation on the day of transplantation, and to investigate whether there is abnormal endometrial peristalsis in patients with repeated failed implantation. Methods: a prospective nested case-control study was conducted. After informed consent of infertile women treated with ART, the data of endometrial peristalsis were collected by transvaginal ultrasound on the day of transplantation, and the frequency and type of endometrial peristalsis were independently analyzed by two analysts at 4 times the normal speed. The women with positive pregnancy outcome were included in the corresponding frozen embryo cycle pregnancy group and the fresh embryo cycle pregnancy group according to their treatment plan. The number of cases in the group were 50 and 17 respectively. The number of women who failed repeatedly in the frozen embryo cycle-RIF group and the fresh embryo cycle-RIF group were 32 and 11, respectively. The frequency and type of endometrial peristalsis in RIF group and pregnancy group were compared. Results: 1. For the frequency of endometrial peristalsis, the frequency of peristaltic wave in RIF group was significantly higher than that in pregnancy group (2.28 卤0.58vs.1.81 卤0.64P0.01). The fresh embryo cycle-RIF group was slightly higher than that of fresh embryo cycle-pregnancy group (1.93 卤0.36vs.1.64 卤0.67P0. 2). The frozen embryo cycle RIF group was significantly higher than that of frozen embryo cycle pregnancy group (2.40 卤0.59vs.1.88 卤0.62p0.01). 2. The frequency of endometrial peristalsis was positively correlated with the number of transplant cycles in RIF group (r = 0.34, P 0.028), but not with the number of transplant cycles in pregnancy group (r = 0.034, P = 0.78). 3. For different types of endometrial peristaltic waves, there was no significant difference between RIF group and pregnancy group in both fresh and frozen embryo cycles (P0.05). 4. For different types of endometrial peristaltic waves, there was no significant difference between RIF group and pregnancy group in both fresh and frozen embryo cycles (P0.05). Conclusion: 1. The increased frequency of endometrial peristalsis may be one of the reasons that affect the implantation of embryos in patients with repeated implantation failure. 2. The frequency of endometrial peristalsis was positively correlated with the number of transplant cycles.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.8
【参考文献】
相关期刊论文 前1条
1 叶冬青;巢式病例对照研究的设计及分析[J];疾病控制杂志;2001年01期
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