不孕症患者促排卵治疗对子宫内膜息肉发生的影响

发布时间：2018-11-10 20:34

【摘要】：目的:探讨不孕症患者促排卵治疗与子宫内膜息肉发生的关系,阐明促排卵治疗中影响子宫内膜息肉发生的因素。方法:收集于门诊行宫腔镜检查的76例做过促排卵治疗的不孕患者,分析不孕类型、不孕年限、促排卵治疗周期数和促排卵治疗中是否应用过促性腺激素释放激素类似物(GnRHa)与子宫内膜息肉发生的关系。结果:在促排卵治疗的不孕患者中,不同不孕类型患者间子宫内膜息肉发生率比较差异无统计学意义(χ2=0.071,P=0.790);不同不孕年限患者间子宫内膜息肉发生率比较差异无统计学意义(χ2=1.561,P=0.458);而不同促排卵治疗周期数患者间子宫内膜息肉发生率比较差异有统计学意义(χ2=4.992,P=0.025);促排卵治疗中是否应用过GnRHa患者间子宫内膜息肉发生率比较差异有统计学意义(χ2=18.899,P=0.000)。在经过促排卵治疗的患者中,随着促排治疗周期数的增加,不孕患者子宫内膜息肉的发生率增加,经过3个以上促排卵治疗周期的不孕患者子宫内膜息肉发生率高于经过1~2个促排卵治疗周期者(52.4%vs25.5%,P=0.025)。在促排卵治疗中应用过GnRHa的不孕患者子宫内膜息肉发生率明显低于未应用过GnRHa的患者(16.0%vs 65.4%,P=0.000)。结论:促排卵治疗周期数的增加是不孕患者子宫内膜息肉发病的相关危险因素,而GnRHa可抑制不孕患者子宫内膜息肉的发生。
[Abstract]:Objective: to investigate the relationship between ovulation promotion therapy and endometrial polyp in infertile women, and to elucidate the factors affecting the occurrence of endometrial polyps in ovulation promotion therapy. Methods: 76 infertile patients who had been treated with ovulation promotion were collected from the outpatient department for hysteroscopy, and the type of infertility and the length of infertility were analyzed. The relationship between the number of cycles of ovulation and the use of gonadotropin releasing hormone analogue (GnRHa) in ovulation induction therapy and the occurrence of endometrial polyps. Results: there was no significant difference in the incidence of endometrial polyps among the infertile patients with different infertility types (蠂 ~ 2 / 0.071P ~ (0.790). There was no significant difference in the incidence of endometrial polyps among patients with different infertile years (蠂 2 1.561 P < 0. 458). The incidence of endometrial polyps in patients with different cycles of ovulation promotion was significantly different (蠂 ~ 2 = 4.992P ~ 0. 025). There was a significant difference in the incidence of endometrial polyps between the patients who had been treated with GnRHa during ovulation promotion (蠂 2 / 18.899P = 0.000). The incidence of endometrial polyps in infertile women increased with the number of cycles of ovulation promotion treatment. The incidence of endometrial polyps in infertile women after more than 3 cycles of ovulation promotion treatment was higher than that in those after 1 ~ 2 cycles of ovulation promotion treatment (52.4 vs 25.5P0. 025). The incidence of endometrial polyps in infertile women who had been treated with GnRHa during ovulation promotion was significantly lower than that in patients without GnRHa (16.0%vs 65.4% P0. 000). Conclusion: the increase of the number of ovulatory treatment cycles is the risk factor of endometrial polyps in infertile patients, while GnRHa can inhibit the occurrence of endometrial polyps in infertile patients.
【作者单位】：吉林大学第二医院妇产科;吉林大学基础医学院组织学与胚胎学系;
【基金】：吉林省科技厅科技发展计划项目资助课题(20130413026GH)
【分类号】：R711.6

【参考文献】