地中海贫血对孕妇妊娠结局影响的系统评价

发布时间：2018-11-11 14:29

【摘要】：目的:综合评价地中海贫血对孕妇妊娠结局的影响,旨为临床决策提供依据。方法:检索Medline、Elsevier、Cochrane Library、ISI web of knowledge、EMBase、相关期刊论文(CNKI)、维普中文科技期刊数据库(VIP)、万方数据库、中国生物医学文献数据库(CBM)从1980年1月至2014年10月发表的关于地中海贫血与孕妇妊娠结局的队列研究,经文献筛选和数据提取后采用Rev Man5.2软件进行Meta分析,采用亚组分析的方法分析异质性的来源,采用漏斗图分析发表偏倚。结果:地中海贫血是孕妇剖宫产、早产发生的危险因素(RR=1.35,95%CI=1.19~1.54,P=0.00;RR=2.06,95%CI=1.29~3.28,P=0.00),但不是新生儿低体质量发生的危险因素(RR=1.56,95%CI=0.98~2.49,P=0.06)。经亚组分析后,α地中海贫血不是孕妇剖宫产、早产、新生儿低体质量发生的危险因素(RR=1.32,95%CI=0.92~1.91,P=0.14;RR=1.21,95%CI=0.51~2.86,P=0.67;RR=1.27,95%CI=0.52~3.10,P=0.59);β地中海贫血是剖宫产、新生儿低体质量发生的危险因素,且发生风险分别是正常孕妇的1.54倍和2.31倍(RR=1.54,95%CI=1.20~1.97,P=0.00;RR=2.31,95%CI=1.04~5.14,P=0.04),但β地中海贫血不是孕妇早产发生的危险因素(RR=2.53,95%CI=0.78~8.18,P=0.12)。结论:地中海贫血是孕妇剖宫产、早产发生的危险因素,β地中海贫血为剖宫产、新生儿低体质量发生的危险因素。
[Abstract]:Objective: to evaluate the effect of thalassemia on pregnancy outcome of pregnant women. Methods: Medline,Elsevier,Cochrane Library,ISI web of knowledge,EMBase, Chinese periodical full-text database (CNKI), Weipu Chinese sci-tech periodical database (VIP), Wanfang database was searched. A cohort study on thalassemia and pregnancy outcome of pregnant women published by (CBM) from January 1980 to October 2014 was analyzed by Rev Man5.2 software after literature screening and data extraction. Subgroup analysis was used to analyze the source of heterogeneity and funnel graph was used to analyze publication bias. Results: thalassemia was the risk factor of cesarean section and premature delivery (RR=1.35,95%CI=1.19~1.54,P=0.00;). RR=2.06,95%CI=1.29~3.28,P=0.00, but not as a risk factor for low body mass in newborns (RR=1.56,95%CI=0.98~2.49,P=0.06). After subgroup analysis, 伪 thalassemia was not a risk factor for cesarean section, premature delivery, and neonatal low body mass (RR=1.32,95%CI=0.92~1.91,P=0.14;RR=1.21,95%CI=0.51~2.86,P=0.67;). RR=1.27,95%CI=0.52~3.10,P=0.59); 尾 -thalassemia is a risk factor for cesarean section and neonatal low body mass, and the risk is 1.54 times and 2.31 times higher than that of normal pregnant women (RR=1.54,95%CI=1.20~1.97,P=0.00;). RR=2.31,95%CI=1.04~5.14,P=0.04, but 尾-thalassemia is not a risk factor for preterm delivery (RR=2.53,95%CI=0.78~8.18,P=0.12) in pregnant women. Conclusion: thalassemia is the risk factor of cesarean section and preterm delivery, 尾 -thalassemia is the risk factor of cesarean section and neonatal low body mass.
【作者单位】：重庆医科大学公共卫生与管理学院妇幼卫生与儿童少年卫生学教研室;
【分类号】：R714.254

【参考文献】