双酚A与不明原因复发性流产发生关系的病例对照研究
发布时间：2018-11-12 10:52
【摘要】：目的探讨环境主要污染物——类雌激素双酚A对女性复发性流产(胚胎停育)的影响。方法收集2014年10月至2016年4月第三军医大学西南医院妇产科门诊不明原因复发性流产或胚胎停育患者80例,选择80例正常妊娠妇女为对照组,使用固相萃取-同位素内标-高效液相色谱质谱联用法检测血清双酚A浓度,按年龄、体质量指数(BMI)、孕周、初潮年龄分组并进行比较,采用单因素和多因素非条件logistic回归模型分析双酚A与复发性流产发生的关联。结果病例组血清双酚A浓度高于对照组[39.51(19.72,57.13)vs 3.56(2.46,6.88)ng/m L,P0.01];多因素logistic回归分析结果显示:双酚A是复发性流产的危险因素(OR=2.469)。两组间比较,双酚A浓度在年龄≤35岁、BMI、孕周、初潮年龄差异均有统计学意义(P0.001)。结论双酚A可能与女性复发性流产(胚胎停育)有关。
[Abstract]:Objective to investigate the effect of estrogenic bisphenol A (BPA), a major environmental pollutant, on recurrent abortion in women. Methods from October 2014 to April 2016, 80 patients with recurrent abortion or fetal suspension were collected from the outpatient department of Gynecology and Obstetrics, Southwest Hospital of the third military Medical University, and 80 normal pregnant women were selected as the control group. Serum bisphenol A concentration was determined by solid-phase extraction (SPE) -isotopic internal standard and high performance liquid chromatography-mass spectrometry (HPLC-MS). Serum bisphenol A concentration was determined by age, body mass index (BMI),) gestational age, menarche age, and compared. Univariate and multivariate non-conditional logistic regression models were used to analyze the association between bisphenol A and recurrent abortion. Results the serum bisphenol A concentration in the case group was higher than that in the control group [39.51 (19.72 卤57.13) vs 3.56 (2.46 卤6.88) ng/m P0.01]. Multivariate logistic regression analysis showed that bisphenol A was a risk factor for recurrent abortion (OR=2.469). The difference of bisphenol A concentration in age 鈮，
本文编号：2326895
[Abstract]:Objective to investigate the effect of estrogenic bisphenol A (BPA), a major environmental pollutant, on recurrent abortion in women. Methods from October 2014 to April 2016, 80 patients with recurrent abortion or fetal suspension were collected from the outpatient department of Gynecology and Obstetrics, Southwest Hospital of the third military Medical University, and 80 normal pregnant women were selected as the control group. Serum bisphenol A concentration was determined by solid-phase extraction (SPE) -isotopic internal standard and high performance liquid chromatography-mass spectrometry (HPLC-MS). Serum bisphenol A concentration was determined by age, body mass index (BMI),) gestational age, menarche age, and compared. Univariate and multivariate non-conditional logistic regression models were used to analyze the association between bisphenol A and recurrent abortion. Results the serum bisphenol A concentration in the case group was higher than that in the control group [39.51 (19.72 卤57.13) vs 3.56 (2.46 卤6.88) ng/m P0.01]. Multivariate logistic regression analysis showed that bisphenol A was a risk factor for recurrent abortion (OR=2.469). The difference of bisphenol A concentration in age 鈮，
本文编号：2326895
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