银连茵陈汤联合熊去氧胆酸治疗妊娠肝内胆汁淤积症的临床疗效评价

发布时间：2018-11-13 20:28

【摘要】：目的:缓解妊娠期瘙痒症状,恢复肝功能,降低血清总胆汁酸(TBA)、血甘胆酸(CG),从而降低胎儿宫内窘迫、围生儿患病率、死亡率和产后出血。方法:用回顾性的方法随机选择门诊服用银连茵陈汤联合熊去氧胆酸的妊娠肝内胆汁淤积(ICP)患者54例;观察银连茵陈汤联合熊去氧胆酸治疗ICP的疗效。结果:ICP患者服用银连茵陈汤联合熊去氧胆酸后,其瘙痒级别降低,各项实验室指标也明显低于治疗前。结论:银莲茵陈汤联合熊去氧胆酸这较传统的治疗方法能改善ICP患者皮肤瘙痒症状,恢复肝功能,血ALT、TBA、CG明显下降从而改善妊娠结局。且对治疗未达痊愈及复发患者,重复使用此方剂,仍有良好的治疗效果。疗效确切,对母婴无副作用,是我院治疗ICP首选的安全有效的药物。
[Abstract]:Objective: to alleviate the symptoms of pruritus during pregnancy, restore liver function, reduce serum total bile acid (TBA), serum cholic acid (CG),) and thus reduce fetal distress, perinatal morbidity, mortality and postpartum hemorrhage. Methods: 54 patients with intrahepatic cholestasis of pregnancy (ICP) treated with Yinlianyin Chen decoction and ursodeoxycholic acid were randomly selected to observe the efficacy of Yinlianyin Chen decoction combined with ursodeoxycholic acid in the treatment of ICP. Results: after ICP patients were treated with Yinlianyin Chen decoction combined with ursodeoxycholic acid, their pruritus grade was decreased, and the laboratory indexes were significantly lower than those before treatment. Conclusion: Yinlian Yinchen decoction combined with ursodeoxycholic acid can improve the symptoms of pruritus, restore liver function, decrease blood ALT,TBA,CG and improve pregnancy outcome in patients with ICP. In addition, the repeated use of this prescription still has a good therapeutic effect on the patients who are not cured or relapsed. The curative effect is definite, no side effect to mother and child, it is the first safe and effective drug in our hospital to treat ICP.
【作者单位】：苏州市立医院;
【分类号】：R714.255

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