子宫内膜癌变hMSH6与p53表达的意义

发布时间：2018-11-16 08:28

【摘要】：目的子宫内膜癌因其逐年上升的发病率和年轻化趋势而备受关注,深入研究其癌变机制,对于子宫内膜癌的防治具有重要意义。本研究分析子宫内膜样腺癌、子宫内膜不典型增生和子宫内膜增生不伴非典型性内膜中hMSH6和p56的表达,探讨hMSH6和p53在子宫内膜癌变过程中的表达相关性及临床意义。方法用免疫组化法检测滨州医学院附属医院病理科2010-08-01-2013-03-01刮宫及手术切除的65例子宫内膜癌,15例子宫内膜不典型增生及20例子宫内膜增生不伴非典型性组织中p53和hMSH6的表达情况,统计学分析其表达水平与临床病理因素之间的相关性。结果子宫内膜样腺癌组织hMSH6蛋白表达率为27.6%(18/65),明显低于子宫内膜不典型增生组织75.0%(15/20),及子宫内膜增生不伴非典型性组织73.3%(11/15)。子宫内膜样腺癌组织p53蛋白表达率55.3%(36/65),明显高于子宫内膜不典型增生组织13.3%(2/15),及子宫内膜增生不伴非典型性5.0%(1/20),其中子宫内膜样腺癌组hMSH6及p53的表达与子宫内膜不典型增生组及子宫内膜增生不伴非典型性组织相比差异有统计学意义(χ~2=10.99,P=0.002;χ~2=10.99,P=0.004),而子宫内膜增生不伴非典型性组织与子宫内膜不典型增生组相比差异无统计学意义,P0.05;hMSH6及p53蛋白的表达均与手术病理分期和组织学分级有关,均P0.001。结论 hMSH6基因表达缺失及p53蛋白的表达与子宫内膜癌的发生有关,通过检测两者的表达水平可对子宫内膜癌的早期预防,早期诊断提供重要依据。
[Abstract]:Objective endometrial carcinoma has attracted much attention because of its increasing incidence and young age. It is of great significance to study the carcinogenesis mechanism of endometrial carcinoma. In this study, the expression of hMSH6 and p56 in endometrioid adenocarcinoma, endometrial atypical hyperplasia and endometrial hyperplasia without atypical endometrium was analyzed, and the expression of hMSH6 and p53 in endometrial carcinogenesis was investigated. Methods Sixty-five cases of endometrial carcinoma were examined by immunohistochemical method in Department of Pathology, affiliated Hospital of Binzhou Medical College, 2010-08-01-2013-03-01 and surgically resected endometrial carcinoma. The expression of p53 and hMSH6 in 15 cases of endometrial atypical hyperplasia and 20 cases of endometrial hyperplasia without atypical tissue was analyzed statistically. Results the expression rate of hMSH6 protein in endometrial adenocarcinoma was 27.6% (18 / 65), which was significantly lower than that in endometrial atypical hyperplasia (75.0%). And endometrial hyperplasia without atypical tissue 73.3% (11 / 15). The expression rate of p53 protein in endometrial adenocarcinoma was 55.3% (36 / 65), which was significantly higher than that in atypical endometrial hyperplasia (13. 3%) and endometrial hyperplasia without atypical type (5. 0%) (1 / 20). The expression of hMSH6 and p53 in endometrioid adenocarcinoma group was significantly higher than that in atypical endometrial hyperplasia group and endometrial hyperplasia without atypical tissue (蠂 ~ 2 + 10.9% P0. 002). There was no significant difference between endometrial hyperplasia without atypical tissue and endometrial atypical hyperplasia (P 0.05). The expression of hMSH6 and p53 protein were related to the pathological stage and histological grade of operation (P 0.001). Conclusion the loss of hMSH6 gene expression and the expression of p53 protein are related to the occurrence of endometrial carcinoma. The detection of the expression level of both genes may provide important evidence for early prevention and early diagnosis of endometrial carcinoma.
【作者单位】： 滨州医学院附属医院病理科;
【基金】：山东省自然科学基金(ZR2013HQ018) 烟台市科技发展计划(2013ZH098) 滨州市科技发展计划(2014ZC0324)
【分类号】：R737.33

【相似文献】

相关期刊论文 前7条

1 周琦,田桂兰,肖觉,唐郢;子宫内膜癌p53表达的临床意义研究[J];肿瘤防治杂志;2003年08期

2 车耀润,张朝,吕申,刘玲,王朝晖;子宫颈癌错配修复基因产物与p53表达[J];中国肿瘤;2005年11期

3 刘召芬,程红英,江森;子宫内膜癌微卫星不稳定性和p53表达的临床意义[J];浙江肿瘤;2000年04期

4 梁英;董颖;;子宫内膜癌中c-myc与P53表达[J];内蒙古医学杂志;2008年07期

5 刘丽萍,孙丽君;卵巢癌化疗中bcl-2,bax与p53表达的意义[J];遵义医学院学报;2002年06期

6 罗琼;邵少慰;刘曙光;雷斌;申洪;;宫颈病变Ki67和P53表达的定量分析及其临床意义[J];中国体视学与图像分析;2013年03期

7 ;[J];;年期

相关硕士学位论文 前3条

1 刘宁;子宫内膜癌雌、孕激素受体、P53表达及意义[D];山东大学;2010年

2 王培;子宫脱垂患者主韧带组织中ER-α、β亚型和P53表达的关系及意义[D];河北医科大学;2013年

3 赵洪伟;宫颈癌中Ebp1与p53表达的相关性分析及临床意义[D];延边大学;2014年

，

本文编号：2335015