体外受精新鲜周期移植失败后冻融周期成功妊娠相关因素分析
发布时间：2018-11-16 08:49
【摘要】：目的探讨体外受精与胚胎移植助孕治疗的不孕症患者新鲜周期移植失败后冻融周期成功妊娠的相关影响因素。方法回顾性分析2012年1月至2014年4月在安徽医科大学第一附属医院生殖医学中心接受长方案超促排卵体外受精-胚胎移植(IVF-ET)助孕治疗的1165例不孕症患者的临床资料,包括新鲜周期妊娠组830个周期与新鲜周期未孕而冻融周期妊娠的335个周期,采用独立样本t检验和χ2检验对2组间相关临床参数进行比较,将筛选出差异有统计学意义的因素进行多因素Logistic回归检验。结果 Logistic回归分析发现,人绒毛膜促性腺激素(HCG)注射日雌二醇(E2)水平在50%~75%之间(OR=1.876,P=0.006,95%CI 1.199~2.935)及E2水平≥75%(OR=1.952,P=0.002,95%CI 1.276~2.985)和HCG注射日子宫内膜厚度(OR=0.882,P0.001,95%CI 0.824~0.944)是新鲜周期能否妊娠的独立影响因素。结论 HCG注射日血清E2水平上升明显和内膜厚度条件欠佳的患者,可建议放弃新鲜周期移植,采用冻融周期移植。
[Abstract]:Objective to investigate the factors related to the successful pregnancy of freeze-thaw cycle after the failure of fresh cycle transplantation in infertile patients treated with in vitro fertilization and embryo transfer assisted pregnancy. Methods from January 2012 to April 2014, the clinical data of 1165 infertile patients who were treated with in vitro fertilization and embryo transfer (IVF-ET) assisted pregnancy therapy at the Center of Reproductive Medicine, the first affiliated Hospital of Anhui Medical University, were retrospectively analyzed. Three hundred and thirty-five cycles including 830 cycles in fresh cycle pregnancy group and 335 cycles in freeze-thawed pregnancy group were compared with each other by independent sample t test and 蠂 2 test. Multivariate Logistic regression test was performed on the factors with statistical significance. Results Logistic regression analysis showed that estradiol (E _ 2) level was between 50% and 75% (OR=1.876,P=0.006,95%CI 1.1992.935) and E _ 2 level 鈮，
本文编号：2335068
[Abstract]:Objective to investigate the factors related to the successful pregnancy of freeze-thaw cycle after the failure of fresh cycle transplantation in infertile patients treated with in vitro fertilization and embryo transfer assisted pregnancy. Methods from January 2012 to April 2014, the clinical data of 1165 infertile patients who were treated with in vitro fertilization and embryo transfer (IVF-ET) assisted pregnancy therapy at the Center of Reproductive Medicine, the first affiliated Hospital of Anhui Medical University, were retrospectively analyzed. Three hundred and thirty-five cycles including 830 cycles in fresh cycle pregnancy group and 335 cycles in freeze-thawed pregnancy group were compared with each other by independent sample t test and 蠂 2 test. Multivariate Logistic regression test was performed on the factors with statistical significance. Results Logistic regression analysis showed that estradiol (E _ 2) level was between 50% and 75% (OR=1.876,P=0.006,95%CI 1.1992.935) and E _ 2 level 鈮，
本文编号：2335068
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