脂肪酸的摄入与子宫内膜癌相关性的荟萃分析

发布时间：2018-11-22 08:00

【摘要】：目的:系统评价脂肪的摄入与子宫内膜癌发病风险间的相关性。方法 :采用计算机检索Pub Med、Web of science、EMbase、CBM、维普数据库、万方数据库,查找有关脂肪酸摄入与子宫内膜癌发病风险间相关性的流行病研究,文献检索时限至2016年6月止。所有文献均由2位研究者严格地按照纳入和排除标准筛选和提取,采用Stata11.0软件分别对总脂肪、饱和脂肪酸、多不饱和脂肪酸及单一不饱和脂肪酸进行荟萃分析。结果 :最终纳入16篇研究,共6 480个研究对象。结果显示,与低摄入量人群相比,高总脂肪[OR=1.22,95%CI为1.02~1.46)、高饱和脂肪酸(OR=1.21,95%CI为1.00~1.47)摄入均增加了子宫内膜癌的发病危险。在亚型分析中,病例对照组合并OR值后亦显示,高总脂肪(OR=1.39,95%CI为1.14~1.70)、高饱和脂肪酸(OR=1.34,95%CI为1.13~1.60)摄入增加了子宫内膜癌的发病危险;在队列研究中未发现总脂肪酸水平与子宫内膜癌发病间具有相关性。在美国(OR=1.39,95%CI为1.00~1.93)的高能量饮食摄入人群(OR=2.17,95%CI为1.57~2.99)和吸烟人群(OR=1.30,95%CI为1.04~1.62)中,饱和脂肪酸高摄入均增加了子宫内膜癌的发病风险。结论:病例对照研究显示,高摄入总脂肪及饱和脂肪酸升高了子宫内膜癌的发病风险。美国的高能量饮食摄入人群及吸烟人群中,饱和脂肪酸高摄入增加子宫内膜癌的发病风险。但尚未发现不饱和脂肪酸与子宫内膜癌发生间存在相关性。仍需纳入更多的流行病学研究,以探讨脂肪摄入与子宫内膜癌间的相关性。
[Abstract]:Objective: to evaluate the relationship between fat intake and risk of endometrial carcinoma. Methods: the Pub Med,Web of science,EMbase,CBM, Wiper database and Wanfang database were searched by computer to find out the relationship between fatty acid intake and the risk of endometrial carcinoma. All literatures were screened and extracted according to the inclusion and exclusion criteria strictly by two researchers. The total fat, saturated fatty acid, polyunsaturated fatty acid and monounsaturated fatty acid were analyzed by Stata11.0 software. Results: a total of 6 480 subjects were included in 16 studies. The results showed that high total fat (OR=1.22,95%CI = 1.02g / 1.46) and high saturated fatty acid (OR=1.21,95%CI = 1.00 / 1.47) increased the risk of endometrial carcinoma compared with low intake population. In the subtype analysis, the high total fat (OR=1.39,95%CI = 1.14 ~ 1.70) and the high saturated fatty acid intake (OR=1.34,95%CI = 1.131.60) also increased the risk of endometrial carcinoma. In the cohort study, no correlation was found between total fatty acid levels and the incidence of endometrial carcinoma. In the United States (OR=1.39,95%CI = 1.00 to 1.93) and smoking (OR=1.30,95%CI = 1.04g / 1.62), high energy diet intake (OR=2.17,95%CI = 1.572.99) and smoking (1.57-1.99), High intake of saturated fatty acids increased the risk of endometrial cancer. Conclusion: high intake of total fat and saturated fatty acids increased the risk of endometrial carcinoma. High intake of saturated fatty acids increases the risk of endometrial cancer in high energy intake and smoking populations in the United States. But there is no correlation between unsaturated fatty acids and endometrial carcinoma. More epidemiological studies are needed to explore the association between fat intake and endometrial carcinoma.
【作者单位】：江苏省南京医科大学第一附属医院神经外科;江苏省盛泽医院神经外科;
【基金】：国家自然科学基金(81473013、81673210) 江苏省高校“青蓝工程”
【分类号】：R737.33

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