同型半胱氨酸与妊娠期高血压疾病的相关性探讨

发布时间：2018-11-23 08:16

【摘要】：目的：探讨血清同型半胱氨酸(homocysteine, HCY)与妊娠期高血压疾病的关系。评价HCY对妊高症的预防、诊断和治疗的临床意义,为临床协助诊断、了解病情、预防病情的发生、发展提供实验性理论依据,从而延长妊娠期高血压疾病患者的妊娠周数及降低其发病率。方法：选择2013年1月—2014年2月在我院门诊产前检查或住院的正常妊娠孕妇90名(A组),其中包括正常早期妊娠孕妇30名、正常中期妊娠孕妇30名、正常晚期妊娠孕妇30名；妊娠期高血压疾病妊娠晚期患者60名(B组),包括子痫前期60例(轻度32例,重度28例)；非妊娠健康体检者30名(C组)。三组年龄均为(26.3±6.7)岁,所有研究对象均无原发性高血压、心血管疾病及糖尿病等合并症,均无肝肾等疾病。取样前两周内除正常饮食外,均未给予叶酸、维生素B12治疗,组间年龄无统计学意义。因孕妇妊娠早期口服叶酸,影响实验结果,故不参与组间对比分析,仅供参考。采用酶联免疫法检测血浆Hcy。结论：(1)正常妊娠的孕妇(中、晚期)的Hcy水平均在正常范围,并随妊娠周数的增加,呈下降趋势(P0.05)。 (2)妊娠期高血压疾病孕妇Hcy水平随的病情的严重程度,呈上升趋势。①轻度子痫前期患者Hcy水平处于正常范围高值(P0.05)； ②重度子痫前期患者Hcy水平高于正常范围(P0.05)； (3)非妊娠健康体检者血浆Hcy均在正常范围,Hcy水平高于正常妊娠(中期、晚期)孕妇组,而低于妊娠期高血压疾病组。
[Abstract]:Objective: to investigate the relationship between serum homocysteine (homocysteine, HCY) and hypertensive disorder complicating pregnancy. To evaluate the clinical significance of HCY in the prevention, diagnosis and treatment of PIH, and to provide experimental theoretical basis for clinical diagnosis, understanding, prevention and development of PIH. Thus prolonging the gestational weeks and reducing the incidence of hypertensive disorder complicating pregnancy. Methods: from January 2013 to February 2014, 90 normal pregnant women (group A), including 30 pregnant women with normal early pregnancy, 30 pregnant women with normal second trimester pregnancy and 30 pregnant women with normal third trimester pregnancy, were selected from outpatient antenatal examination or hospitalization in our hospital from January 2013 to February 2014. There were 60 cases (group B) of hypertensive disorder complicating pregnancy (group B), including 60 cases of preeclampsia (mild 32 cases, severe 28 cases) and 30 cases of non-pregnancy health examination (group C). The age of the three groups was (26.3 卤6.7) years old. No essential hypertension, cardiovascular disease, diabetes mellitus and other diseases were found in all subjects. Except normal diet, folic acid and vitamin B12 were not given in the two weeks before sampling. There was no significant difference in age between groups. Because the pregnant women take folic acid in early pregnancy, it does not participate in the comparative analysis between groups, so it is for reference only. Detection of plasma Hcy. by enzyme-linked immunosorbent assay Conclusion: (1) the levels of Hcy in normal pregnant women (middle and late pregnancy) were in the normal range and decreased with the increase of gestational weeks (P0.05). (2) the level of Hcy in pregnant women with hypertensive disorder complicating pregnancy increased with the severity of the disease. 1 the level of Hcy in the patients with mild preeclampsia was high in the normal range (P0.05); 2the level of Hcy in patients with severe preeclampsia was higher than that in normal range (P0.05); (3) the level of plasma Hcy was in normal range, and the level of Hcy was higher than that of normal pregnant women (middle and late pregnancy), but lower than that of hypertensive disorder complicating pregnancy.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.246

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