炔雌醇环丙孕酮联合二甲双胍治疗多囊卵巢综合征不孕患者的疗效研究

发布时间：2018-11-23 12:21

【摘要】：目的探讨炔雌醇环丙孕酮联合二甲双胍治疗多囊卵巢综合征不孕患者的疗效。方法选取2011年5月~2016年5月我院收治的多囊卵巢综合征不孕患者200例作为研究对象,并将其随机分为观察组与对照组,各100例。对照组患者给予炔雌醇环芮孕酮进行治疗,观察组患者在对照组的基础上联合二甲双胍进行治疗,观察两组患者的临床症状变化情况,比较两组患者治疗前后血清性激素水平情况、疗效情况。结果治疗前,两组患者血清性激素水平情况比较,差异无统计学意义(P0.05),治疗后,观察组患者血清性激素水平改善程度好于对照组,差异有统计学意义(P0.05);观察组患者总有效率为84%,明显高于对照组的61%,组间比较,差异有统计学意义(P0.05)。结论炔雌醇环芮孕酮联合二甲双胍治疗多囊卵巢综合征不孕患者的疗效显著,改善了临床症状和生活质量,临床上值得推广应用。
[Abstract]:Objective to investigate the efficacy of ethylestradiol cycloprogestrel combined with metformin in the treatment of infertility with polycystic ovary syndrome (PCOS). Methods 200 infertile patients with polycystic ovary syndrome (PCOS) from May 2011 to May 2016 were randomly divided into observation group and control group with 100 cases each. The patients in the control group were treated with estradiol cycloplesterone, the patients in the observation group were treated with metformin on the basis of the control group, and the changes of clinical symptoms in the two groups were observed. The serum sex hormone level and curative effect were compared between the two groups before and after treatment. Results before treatment, there was no significant difference in serum sex hormone level between the two groups (P0.05). After treatment, the improvement degree of serum sex hormone level in the observation group was better than that in the control group, and the difference was statistically significant (P0.05). The total effective rate of observation group was 84%, which was significantly higher than that of control group (61%), the difference was statistically significant (P0.05). Conclusion the efficacy of estradiol and metformin in the treatment of infertility with polycystic ovary syndrome is significant, the clinical symptoms and quality of life are improved, and it is worth popularizing in clinic.
【作者单位】：江苏省盐城市妇幼保健院生育技术科;
【分类号】：R711.75;R711.6

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