熊去氧胆酸联合腺苷蛋氨酸治疗妊娠期肝内胆汁於积症的机制

发布时间：2018-11-24 18:09

【摘要】：目的:探究熊去氧胆酸联合腺苷蛋氨酸治疗妊娠期肝内胆汁於积症的机制。方法:选取某院收治的160例妊娠期肝内胆汁於积症患者,按随机数字表法将患者分为观察组和对照组,每组各80例,对照组给予熊去氧胆酸治疗,观察组给予熊去氧胆酸联合腺苷蛋氨酸的治疗,治疗前和治疗后检测妊娠期肝内胆汁於积症患者血液流变学指标、炎症因子、凝血功能和肝功能及相关生化指标的变化情况。结果:与本组治疗前和治疗后的对照组相比,观察组经过熊去氧胆酸联合腺苷蛋氨酸治疗后炎症因子IL-6、IL-8、TNF-α显著降低,IL-10显著升高;凝血功能指标PT变化不明显,APTT、FIB、D-D显著降低,PLT显著升高;血液流变学相关指标及肝功能和相关生化指标(TB、DB、TBA)显著降低,比较差异存在统计学意义(P0.05);与治疗前对照组相比,治疗后对照组炎症因子(IL-6、IL-8、TNF-α)、生化指标、血液流变学、FIB、D-D显著降低(P0.05),IL-10、PLT显著升高(P0.05),PT、APTT变化不明显(P0.05)。结论:熊去氧胆酸联合腺苷蛋氨酸的治疗能够改善妊娠期肝内胆汁於积症患者血液流变学指标、炎症因子、凝血功能和肝功能及相关生化指标,为妊娠期肝内胆汁於积症患者的临床治疗提供帮助。
[Abstract]:Aim: to explore the mechanism of ursodeoxycholic acid combined with adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. Methods: one hundred and sixty patients with intrahepatic cholestasis of pregnancy were randomly divided into observation group (n = 80) and control group (n = 80). The control group was treated with ursodeoxycholic acid. The observation group was treated with ursodeoxycholic acid combined with adenosine methionine. The changes of hemorheology, inflammatory factors, coagulation function, liver function and related biochemical indexes were detected before and after treatment in patients with intrahepatic cholestasis of pregnancy. Results: compared with the control group before and after treatment, the inflammatory factor IL-6,IL-8,TNF- 伪 was significantly decreased and IL-10 was significantly increased in the observation group after treatment with ursodeoxycholic acid and adenosine methionine. There was no significant change in PT, APTT,FIB,D-D decreased significantly and PLT increased significantly. The relative indexes of hemorheology and liver function and related biochemical indexes (TB,DB,TBA) were significantly decreased (P0.05). Compared with the control group before and after treatment, the inflammatory factor (IL-6,IL-8,TNF- 伪), biochemical index, hemorheology and FIB,D-D in the control group decreased significantly (P0.05), and the IL-10,PLT increased significantly (P0.05), PT,). The change of APTT was not obvious (P0.05). Conclusion: ursodeoxycholic acid combined with adenosine methionine can improve hemorheology, inflammatory factors, coagulation function, liver function and related biochemical indexes in patients with intrahepatic cholestasis of pregnancy. To provide assistance for the clinical treatment of intrahepatic cholestasis of pregnancy.
【作者单位】：宜宾市第二人民医院产科;成都市锦江区妇幼保健院产科;宜宾市第二人民医院妇科;
【分类号】：R714.255

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