CysC与宫颈癌早期病变的相关性研究

发布时间：2018-11-29 10:47

【摘要】：目的 :探讨血清胱抑素C(Cystatin C,CysC)与宫颈上皮内瘤变(cervical infraepithelial neoplasia,CIN)及早期宫颈癌的相关性,并评价其在宫颈癌早期诊断中可能的价值。方法:以本院100例CIN患者和103例早期宫颈癌患者作为实验组,同时收集本院150例健康体检者血清作为对照组;用全自动生化分析仪测定实验组及对照组血清CysC的浓度,并对各实验组与对照组的结果采用方差分析、t检验进行比较。结果:CIN组以及早期宫颈癌组中血清CysC的浓度明显高于对照组(P0.01),而CIN组血清CysC的浓度与早期宫颈癌组相比无显著性差异(P=0.18);CysC的浓度在CIN不同阶段无显著性差异(P=0.12)。结论:CysC在CIN与早期宫颈癌患者血清中的表达明显高于对照组,与CIN病变程度无关,提示血清中CysC的检测在CIN患者和宫颈癌早期筛查中具有一定的临床价值。
[Abstract]:Objective: to investigate the relationship between serum cystatin (C (Cystatin) CysC and cervical intraepithelial neoplasia (cervical infraepithelial neoplasia,CIN) and early cervical cancer, and to evaluate its possible value in early diagnosis of cervical cancer. Methods: 100 patients with CIN and 103 patients with early cervical cancer were selected as experimental group and 150 healthy persons as control group. The concentration of serum CysC in experimental group and control group was measured by automatic biochemical analyzer, and the results of each experimental group and control group were compared by ANOVA and t test. Results: the concentration of serum CysC in CIN group and early cervical cancer group was significantly higher than that in control group (P0.01), but the serum CysC concentration in CIN group was not significantly different from that in early cervical cancer group (P0. 18). There was no significant difference in the concentration of CysC in different stages of CIN (P < 0. 12). Conclusion: the expression of CysC in serum of CIN and early cervical cancer patients is significantly higher than that of control group, but not related to the degree of CIN lesion. It suggests that the detection of CysC in serum is of certain clinical value in CIN patients and early cervical cancer screening.
【作者单位】：苏州大学附属第二医院妇产科;苏州大学附属第二医院检验科;
【基金】：苏州科技研究计划(SYS201551) 苏州大学附属第二医院青年科研项目(SDFEYQN1404)
【分类号】：R737.33

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